摘要
目的研究高压氧联合甲钴胺治疗糖尿病周围神经病变的临床疗效。方法临床入选142例2型糖尿病周围神经病变患者,对入选患者按照入院时间先后进行编号,分为对照组和研究组,每组71例,两组均采取严格控制血糖治疗,其中对照组加用甲钴胺治疗,而研究组在对照组的基础上,加用高压氧治疗。随访和分析两组的感觉神经及运动神经的传导速度、H反应潜伏期、血液生化指标以及综合疗效评估等临床资料。结果在治疗后,研究组的运动神经和感觉神经的传导速度较对照组明显增快(P<0.05),胆固醇、甘油三脂、血浆黏度、全血低切还原黏度以及随机血糖水平均较对照组明显改善(P<0.05);对照组的总有效率为63.38%,研究组的总有效率为85.92%,两组之间具有统计学差异(P<0.05)。结论缺血缺氧是糖尿病周围神经病变的主要病理改变,高压氧联合甲钴胺对其具有较好的治疗效果。
Objective To investigate the clinical curative effects of hyperbaric oxygen combined with mecobalamine on patients with type 2 diabetic peripheral neuropathy（DPN）.Methods The 142 clinically selected patients with type 2 DPN were divided into control group and research group with 71 people in each group.Both groups received strict treatment regimen to control blood sugar.Meanwhile the control group received the treatment with mecobalamine,and the research group received hyperbaric oxygen combined with mecobalamine.Follow-up and analysis were made in clinical data of both groups,such as conduction velocity of sensory and motor nerves,H reaction latency,blood biochemical indicators and integrative curative effects.Results After the treatment,the conduction velocity of sensory and motor nerves in the research group increased significantly compared with those in the control group（P〈0.05）.Compared with the control group,the cholesterol,triglyceride,plasma viscosity,whole blood restore viscosity at low shear and random blood sugar level in the research group were significantly improved（P〈0.05）.The total effective rate of the control group was 63.38%,the research group was 85.92%,and the differences were significant between the two groups（P〈0.05）.Conclusion Ischemia and anoxia are the main pathological changes of diabetic peripheral neuropathy.The therapy of hyperbaric oxygen combined with mecobalamine has good therapeutic effects on such diseases.
出处
《西南国防医药》
CAS
2012年第3期255-258,共4页
Medical Journal of National Defending Forces in Southwest China
关键词
2型糖尿病
周围神经病变
高压氧
甲钴胺
type 2 diabetes
peripheral neuropathy
hyperbaric oxygen
mecobalamine
