摘要
目的对比观察顺铂(DDP)单药用于局部晚期鼻咽癌同步放化疗与DDP联合氟尿嘧啶(5-FU)方案(PF方案)同步放化疗的有效性和安全性。方法 76例局部晚期鼻咽癌分为两组,40例接受PF方案同步放化疗(5-FU 500mg/m2静滴,d1～d5;DDP 80mg/m2静滴,d1,21天为1周期),36例接受DDP单药同步放化疗(DDP 40mg/m2静滴,每周1次,共7次)。鼻咽部病灶及颈部阳性淋巴结给予放疗总量为70Gy,颈部预防性照射给予放疗量50Gy。结果全部患者均可评价疗效和毒副反应,PF方案组及DDP单药组有效率均为100%。PF方案组的1、3年生存率分别为100%、85%,DDP单药组分别为100%、89%(P>0.05);PF方案组与DDP单药组的3年无进展生存率分别为77.5%和75.0%(P>0.05);PF方案组的中位生存时间为50.6个月,DDP单药组为48.0个月(P>0.05)。两组毒副反应以恶心呕吐、口腔黏膜炎及白细胞减少为主,差异均有统计学意义(P<0.05)。结论 DDP单药与PF方案用于局部晚期鼻咽癌同步放化疗的疗效相近,患者均可耐受,但DDP单药组反应较轻。
Objective To compare the efficacy and safety of single-agent cisplatin（DDP） or DDP plus fluorouracil（5-FU） regimen（PF regimen） combined with concurrent radiotherapy for locally advanced nasopharyngeal carcinoma.Methods Seventy-six patients with locally advanced nasopharyngeal carcinoma were divided into two groups.Forty patients received chemotherapy of PF regimen jointing concurrent radiotherapy（5-FU 500mg/m2 iv d1-d5,cisplatin 80mg/m2 iv d1;21 days was a cycle）,and 36 patients received chemotherapy of single cisplatin（DDP 40mg/m2 iv once a week for a total of 7 times） with concurrent radiotherapy;nasopharyngeal lesions and positive lymph node were given a total amount of 70Gy,and prophylactic neck radiation was given the amount of 50Gy.Results The efficacy and toxicities could be evaluated.The response rate（RR） was 100% in the two groups（P0.05）.The 1-,3-year overall survival（OS） rate in PF regimen group were 100% and 85%,and in single-agent DDP group were 100% and 89%,respectively（P0.05）.3-year disease-free survival rate in PF regimen group and single-agent DDP group were 77.5% and 75.0%,respectively（P0.05）.The median OS of PF regimen group and single-agent DDP group were 50.6 months and 48.0 months（P0.05）.The main toxicities were nausea/vomiting,oral mucositis and leucopenia.The incidence of them on PF regimen group was higher than that in single-agent DDP group（P0.05）.Conclusion For patients with locally advanced nasopharyngeal carcinoma who accepted RT combining concurrent chemotherapy either DDP alone or PF regimen,the efficacy is similar and toxicities can be tolerated.The toxicities in the group of DDP alone are relatively mild.
出处
《临床肿瘤学杂志》
CAS
2012年第3期229-232,共4页
Chinese Clinical Oncology
关键词
局部晚期鼻咽癌
同步放化疗
预后
毒副反应
Locally advanced nasopharyngeal carcinoma
Concurrent chemoradiotherapy
Prognosis
Toxicity
