摘要
目的观察雌激素受体(ER)、孕激素受体(PR)、原癌基因Her-2(C-erB-2)与肺腺癌骨转移的关系,并对肺腺癌患者出现骨转移的时间及生存期进行多因素相关分析。方法 96例肺腺癌患者入组本研究,通过免疫组化检测术后标本上述受体的表达。结果 ER、PR和C-erB-2的表达在骨转移及非骨转移两组间的差异均无统计学意义(P分别为0.34、0.60、0.26),但骨转移组上述受体一旦表达,表达程度均较高,多为++或+++。T分期、N分期越低,出现骨转移的时间及总生存期(OS)越长。ER和C-erB-2阳性和阴性表达组之间出现骨转移的时间及OS的差异均有统计学意义(P<0.05)。结论 ER、PR、C-erB-2与肺腺癌是否出现骨转移无相关性;ER、C-erB-2与肺腺癌出现骨转移的时间及预后密切相关。
Objective To find the relationship between ER,PR,C-erB-2 and bone metastasis of lung adenocacinoma,and to analz bone metastasis time and survival time of lung adenocacinoma patients by way of multiple factors correlation analysis.Methods Expression levels of ER,PR,and C-erB-2 in 96 lung adenocacinoma patients were investigated by immunohistochemistry（IHC）.Result The level of ER,PR,and C-erB-2 had no difference between the bone metastasis group and the no bone metastasis group（P=0.34,0.60,0.26）,but once they expressed,the level were higher in the bone metastasis group,most were ＋ ＋ or ＋ ＋ ＋.The earlier the T and N stage were,the longer the bone metastasis time and the OS were.Expression of ER and C-erB-2 had a relationship with the time of bone metastasis appearance and the OS（P0.05）.Conclusions ER,PR,and C-erB-2 have no relationship with bone metastasis of lung adenocacinoma;while ER and C-erB-2 have a close relationship with the time of bone metastasis appearance OS of lung adenocacinoma.
出处
《山东大学学报（医学版）》
CAS
北大核心
2012年第4期91-95,100,共6页
Journal of Shandong University:Health Sciences
基金
山东省科技攻关计划基金资助项目(2010GGC03001)
