摘要
目的 研究一氧化氮 (NO)在类风湿性关节炎 (RA)及骨关节炎 (OA)病变中的作用。方法 采用亚硝酸盐间接法测定了 40例RA、2 0例OA患者血清及滑液NO的含量变化 ,并与年龄相匹配的健康人相比较。结果 RA患者血清及滑液NO的浓度呈正相关 (r =0 417,P <0 0 5 )。RA和OA患者血清NO浓度均低于滑液中的 ,但显著高于正常对照组血清NO浓度 ;RA患者滑液NO浓度高于血清中 ,且明显高于OA组滑液NO浓度。结论 NO在RA和OA患者骨关节中可能主要由滑膜产生 ;NO可能参与了类风湿性关节炎病变过程 。
Objective [HT5”SS]To evaluate the role of nitrous oxide (NO) in the pathogenesis of rheumatoid arthritis(RA)and osteoarthritis(OA) [HT5”H]Methods [HT5”SS]The change of NO content in 40 cases of RA and 24 cases of OA of the hip were determined by nitrite indirect method The results were compared with the data obtained from specimens of healthy persons(blood serum specimens) [HT5”H]Results [HT5”SS]In patients with RA,NO concentration in blood serum was positively correlated to that in the synovia( r =0 417,P<0 05) In patients with RA and OA,NO concentration in blood serum was lower than that in synovia,but significantly higher than that in control group NO concentration in synovia in patients with RA was obviously higher than that in patients with OA [HT5”H]Conclusion [HT5”SS]In patients with RA and OA,intra articular NO is mainly synthesised by the synovium The increased NO concentration in blood serum suggested its involvement in the pathogensis of RA [WT5”HZ]
出处
《中国骨伤》
CAS
2000年第5期276-277,共2页
China Journal of Orthopaedics and Traumatology
关键词
类风湿性关节炎
骨关节炎
一氧化氮
WT5”BZ]Arthritis,rheumatoid Osteoarthritis Nitric oxide
