摘要
目的探讨联合检测EB病毒VCA-IgA和Rta-IgG抗体在筛查鼻咽癌高危人群中的应用价值。方法收集6201例体检人群的血清,将血清统一编号后,依序列测定方法,用酶联免疫法(ELISA)对所有人检测VCA-IgA抗体,将VCA-IgA抗体阳性的193例血清再进行Rta-IgG抗体的酶联免疫法(ELISA)测定,比较血清学检查结果中VCA-IgA抗体单项阳性与VCA-IgA和Rta-IgG抗体双项阳性鼻咽癌检出情况,评价联合检测EB病毒抗体在筛查鼻咽癌高危人群中的应用价值。结果在这193例VCA-IgA抗体阳性血清中,Rta-IgG抗体阳性32例。依照血清号查找其体检结果,VCA-IgA抗体阳性中有鼻咽癌4例,VCA-IgA和Rta-IgG抗体双阳性中有鼻咽癌3例。差异有统计学意义(P<0.05)。结论从序列测定获得的双项阳性血清中筛查到的鼻咽癌比率高于单项VCA-IgA阳性血清。联合VCA-IgA和Rta-IgG更适用于鼻咽癌高危人群的筛查。
Objective To discuss the value of joint detection of EB virus VCA-IgA and Rta-IgG antibody which used to screen nasopharyngeal carcinoma in high-risk group.Methods Collected serum samples of 6201 people in physical examination test group.After numbered the samples,using Enzyme-linked immunosorbent assay（ELISA）to detect VCA-IgA antibody of all,then use the same method to detect the VCA-IgA antibody positive samples.Compare the numbers of positive samples of VCA-IgA antibody and VCA-IgA Rta-IgG antibody.Evaluate the value of combination detection of EB virus antibody which used to screen nasopharyngeal carcinoma in high-risk group.Results There are total 193 VCA-IgA antibody positive cases,and 32 samples out of 193 VCA-IgA antibody positive are Rta-IgG antibody positive.Searching the results of physical examination test,4 of the VCA-IgA antibody positive cases were diagnosed nasopharyngeal carcinoma,3 of the VCA-IgA Rta-IgG antibody positive cases were diagnosed nasopharyngeal carcinoma.Difference are statistically significant（P〈0.05）.Conclusion The ratio of the result about combination detecting method（VCA-IgA Rta-IgG antibody） is higher than that only using VCA-IgA antibody.The method of combining VCA-IgA and Rta-IgG is more sutable to screen nasopharyngeal carcinoma in high-risk group.
出处
《中国医药指南》
2012年第10期26-27,共2页
Guide of China Medicine
关键词
鼻咽癌
EB病毒
筛查
Nasopharyngeal carcinoma
EB virus
Screening
