摘要
目的探讨甲状腺激素检测在亚急性甲状腺炎与弥漫性毒性甲状腺肿(Graves病)这两种不同病因的甲状腺毒症中的鉴别诊断价值。方法采用全自动化学发光免疫法检测157例亚急性甲状腺炎甲亢期患者及162例Graves病患者血清中甲状腺激素的含量,包括游离三碘甲状腺原氨酸(fT3)、三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离甲状腺素(fT4),并计算T3/T4、fT3/fT4比值,对比分析各组甲状腺激素水平及T3/T4、fT3/fT4比值特点,研究运用其进行鉴别诊断的临床可行性。结果亚急性甲状腺炎甲亢期组(以下简称亚急性甲状腺炎组)与Graves病组对比,fT3、fT4、T3、T4、T3/T4、fT3/fT4差异有统计学意义(P<0.01)。亚急性甲状腺炎组T4较T3、fT3、fT4升高显著,Graves病组fT3、T3、T4、fT4均升高明显。结论亚急性甲状腺炎甲亢期时甲状腺激素水平变化较Graves病差异显著,甲状腺激素水平以T4相对升高显著时,应考虑亚急性甲状腺炎甲亢期可能,甲状腺激素水平均升高,特别是以fT3、T3升高相对显著时,应考虑Graves病可能。T3/T4=1.76×10-2、fT3/fT4=2.81×10-1可以作为亚急性甲状腺炎甲亢期与Graves病的诊断切点。甲状腺激素检测可以作为鉴别亚急性甲状腺炎与Graves病这两种不同甲状腺毒症的一种简易快速的方法。
Objective To explore clinical significance of serum thyroid hormone levels on the differential diagnosis of thyrotoxicosis which are root in subacute thyroiditis and Graves＇ disease.Methods The serum thyroid hormone levels（fT3,T3,T4,and fT4） in 157 patients with subacute thyroiditis in hyperthyroidism and 162 patients with Graves＇ diseases were detected by Electrochemiluminescence immunoassay.The feasibility of differential diagnosis by using thyroid hormone levels and T3/T4 and fT3/fT4 ratio was analyzed.Results The serum thyroid hormone levels and T3/T4 and fT3/fT4 ratios in subacute thyroiditis group were significantly lower than that in Graves＇ disease（P0.01）.The serum T4 in subacute thyroiditis group increased obviously than T3,fT3 and fT4,while the serum levels of fT3,T3,T4 and fT4 in Graves＇ disease all increased apparently.The ratio of T3/T4=1.76×10-2、fT3/fT4=2.81×10-1 can be seen as the diagnosis point between subacute thyroiditis and Graves＇ disease.Conclusion The detection of serum thyroid hormone could be used to distinguish the subacute thyroiditis and Graves＇ diseases in patients with thyrotoxicosis simply and rapidly.
出处
《标记免疫分析与临床》
CAS
2012年第2期82-85,共4页
Labeled Immunoassays and Clinical Medicine
