摘要
目的检测Ang-2、Tie-2及VEGFR-2在大肠癌组织中的表达,分析其与大肠癌复发、转移的关系。方法采用免疫组化SP法检测54例大肠癌组织、18例大肠癌旁组织中Ang-2、Tie-2、VEGFR-2的表达,探讨其与大肠癌预后的关系。结果①Ang-2、Tie-2、VEGFR-2在大肠癌组织中的阳性表达率分别为77.78%、74.07%及59.26%,显著高于癌旁正常组织的阳性表达率的27.28%、16.67%及22.22%,差异均有统计学意义(P<0.05)。②Ang-2、Tie-2及VEGFR-2在根治术后5年内发生复发转移者的阳性表达率分别为87.50%、75.00%和75.00%,显著高于未复发转移组阳性表达率(分别为44.44%及22.22%、33.33%),差异均有统计学意义(P<0.05)。③Kaplan-Meier生存分析结果表明,Ang-2、Tie-2及VEGFR-2表达阴性者5年生存率均明显高于阳性表达者(P<0.05)。结论 Ang、Tie-2及VEGFR-2的表达与大肠癌复发转移及预后密切相关,可作为预测侵袭转移及评估预后的分子生物学标志物。
Objective To study the expression of Ang-2,Tie-2 and VEGFR-2 in colorectal cancer,and to analyze the relationship between them with recurrence,metastasis and prognosis of colorectal cancer.Methods The expressions of Ang-2,Tie-2 and VEGFR-2 were studied by using immunohistochemical SP in 54 cases with colorectal cancer and in 18 cases of neighboring colorectal cancer tissue.Results The positive rate of Ang-2,Tie-2 and VEGFR-2 in colorectal cancer tissue were respectively 77.78%,74.07% and 59.26%,which were significantly higher than those in neighboring colorectal cancer tissue（positive rate were respectively 27.28%、 16.67% and 22.22%）（P0.05）.The positive rate of Ang-2,Tie-2 and VEGFR-2 in patients who had recurrence metastasis after curative operation within 5 years were respectively 87.50%,75.00% and 75.00%,which were obviously higher than those in non-recurrence metastasis groups positive expression（positive rate were respectively 44.44%,22.22% and 33.33%）（P0.05）.The results of Kaplan-Meier survival analysis showed that five-year overall survival rates of patients who had negative expression of Ang-2,Tie-2 and VEGFR-2 were obviously higher than those who had positive expression（P0.05）.Conclusion The expression of Ang-2,Tie-2 and VEGFR-2 are closely correlated to the recurrence metastasis and prognosis of colorectal cancer,all of them could be the molecular markers for both predicting invasion metastasis and assessing prognosis.
出处
《宁夏医学杂志》
CAS
2012年第4期295-297,F0003,共4页
Ningxia Medical Journal
基金
宁夏自然科学基金资助项目(NZ0899)
关键词
大肠癌
血管生成素-2
血管生成素受体-2
血管内皮细胞生长因子受体-2
免疫组化
Colorectal Cancer
Angiogenin-2
Tyrosine Kinase with Immunoglobulin-like and Epidermal Growth Factor Homology Domains
Vascular Endothelial Growth Factor-2
