摘要
目的:探讨不同胎龄早产儿凝血功能状态及低纤维蛋白原输注冷沉淀后的疗效分析。方法:①选择126例早产儿,按胎龄分为<32孕周组、≥32～<35孕周组、≥35～37孕周组,设50例正常足月新生儿为对照组,在出生后的24h内检测凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D-二聚体(D-D)及血小板计数(PLT),分析早产儿凝血功能状态。②对其中55例纤维蛋白原浓度低于0.8g/L的早产儿进行冷沉淀输注,输注完2h内测定FIB、PT、APTT、TT、D-D及PLT,并与输注前进行比较分析。结果:①与对照组比较,早产儿PT、APTT、TT明显增高(P<0.01),FIB明显降低(P<0.01),D-D增高(P<0.05),PLT差异无统计学意义(P>0.05)。②<32孕周组与≥35～37孕周组比较PT、APTT、TT、D-D增高(P<0.05),FIB降低(P<0.05),PLT无明显差异(P>0.05)。③55例早产儿输注冷沉淀后FIB明显增高(P<0.01),PT、APTT降低(P<0.05),TT、D-D差异无统计学意义(P>0.05)。结论:早产儿凝血功能比正常足月新生儿低下,胎龄越低凝血功能障碍越严重,临床应尽早重视其凝血功能状态;对纤维蛋白原浓度低于0.8g/L的早产儿应尽早输注冷沉淀,在改善早产儿预后及提高成活率方面具有积极的临床意义。
Objective：To discuss the blood coagulation function in premature infants with different gestational age, analysis the effect of treatment after cryoprecipitate transfusion in low fibrinogen of premature infants. Method： ①The 126 cases were divided into three groups according to gestational age：〈32 weeks group ,≥32--G35 weeks group and ≥35 --37 weeks group. Pprothrombin time （PT）, part-time activation thromboplastin （APTT）, thrombin time （TT）, fibrin- ogen （FIB）, D-dimer （D-D） and platelet account（PLT） within after born 24 hours of the three groups and 50 full term infants（control group） were detected, and the condition of blood coagulation function were analyzed. ②55 premature in- fants with low fibrinogen（〈0.8 g/L ） were received cryoprecipitate transfusion, and FIB, PT, APTT, TT,D-D within after transfusion 2 hours were detected, and the changes of blood coagulation function were analyzed compared with before transfusion. Result： ①Compared with control group,PT, APTT and TT in premature infants group were significantly in- creased （ P〈0.01）, FIB was significantly decreased （ P〈0.01）, D-D was increased （ P〈0. 05）, and PLT was no significantly difference（ P 〉0.05）. ②Compared with G35--37 weeks group, PT,APTT,TT and D-D of 〈32 weeks group were increased （ P〈0.05）, FIB was decreased （ P〈0.05）, PLT was no significantly difference（ P 〉0.05）. ③ Compared with before cryoprecipitate transfusion, the blood coagulation function in 55 premature infants after transfu- sion, FIB was significantly increased （ P〈0.01）, PT and APTT decreased （ P〈0.05）, TT and D-D were no signifi- cantly differences（ P〉0.05）. Conclusion：The blood coagulation function in premature infants was lower than that of full term infants, lower gestational age of the infant was more serious, therefore, clinician should attach importance to blood coagulation function as soon as possible. For premature infants with low fibrinogen（〈0.8 g/L ）, it should be received eryoprecipitate transfusion as possible as early, which would be of positive clinical significance in improving prognosis and raising survival rate .
出处
《临床血液学杂志（输血与检验）》
CAS
2012年第2期212-214,共3页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
关键词
早产儿
胎龄
凝血功能
冷沉淀
输注
预后
成活率
premature infant
gestational age
blood coagulation function
cryoprecipitate
transfusion
prognosis
survival rate
