摘要
目的探讨中国近23年肝脏血管平滑肌脂肪瘤（HAML）的流行病学特征和诊治经验。方法联合检索中国知网和维普网有关HAML的文献，获取相关信息，对患者的临床资料进行回顾性分析。结果中国自1987年7月至2010年12月共报道523例HAML，男女比例为1：2．63，平均年龄41．7岁，平均年龄在35-55岁之间者占总病例数的81．84％。76．42％的病例分布在华东、华北地区；66．92％无症状；明确诊断需依靠病理及免疫组织化学染色，肿瘤表达HMB-45、SMA、Vimentin、CD117阳性率分别为98．85％、96．10％、65．85％、40．71％。治疗方法以手术切除为主。结论HAML多发于中青年女性；华东、华北地区病例最多；由于HAML临床表现无特异性、影像学表现多样，术前正确诊断率较低；大部分患者需依靠术后病理及免疫组化明确诊断，肿瘤细胞表达HMB-45、SMA阳性，是诊断HAML的可靠依据。手术切除为主要治疗手段，预后良好。
Obiective To probe the epidemiological characteristics of hepatic angiomvolipoma （ HAML ） and its diagnosis and treatment in China in the past 23 years. Methods The reports about HAML which published in China National Knowledge Infrastructure （CNKI） and VIP Database were searched together, and the relevant information on epidemiological features, diagnosis and treatment of HAML, and the clinical data were retrieved and analyzed retrospectively. Results A total of 523 patients with HAML were reported in China from Jul. 1987 to Dec. 2010. The ratio of males to females was approximately 1：2.63; the average age was 41.7 years, and the patients whose ages from 35 to 55 years old accounted for 81.86 %. About 76.42% of the patients were distributed in east and north China. The patients without symptoms accounted for approximately 66.92 %. It needed to rely on the pathological and immunohistochemistrv for definite diagnosis, the positive rate of HMB-45, SMA, Vimentin and CD117 which expressed in tumor cells were 98.85%, 96.10%, 65.85% and 40.71%, respectively. Surgical resection was still the main treatment of HAML. Conclusion HAML frequently occurrs in young and middle aged females and mainly distributs in east and north China areas. Due to the nonspecific clinical manifestations and the diversified imaging findings, the rate of preoperative diagnosis of HAML is low, and definite diagnosis of most of patients needs to rely on the pathological and immunohistochemistrv. It is the reliable base to diagnose HAML with the positive of HMB-45 and SMA which expressed by tumor cells, surgical resection that could provide a good prognosis is the main treatment for curing HAML.
出处
《肝胆胰外科杂志》
CAS
2012年第3期183-187,191,共6页
Journal of Hepatopancreatobiliary Surgery
关键词
肝肿瘤
血管平滑肌脂肪瘤
流行病学特征
诊断
治疗
中国
liver neoplasms
angiomvolipoma
epidemiological characteristics
diagnosis
treatment
China
