2Stanssens P,Peter W,Bergum et al.Anticoagulant repertoire of the hookworm Ancylostoma caninum[J].Biochemistry,1996,93:2149-54.
3Duggan BM,Dyson HJ.Inherent flexibility in a potent inhibitor of blood coagulation ,recombinant nematode anticoagulant protein c2[J].Eur J Biochem,1999,265:539-48.
4Bergum PW,Cruikshank A,Maki SL et al.Role of zymogen and activated factor X as scaffolds for the inhibition of the blood coagulation factor VⅡa-tissue factor complex by recombinant nematode anticoagulant protein c2[J].J Biol Chem.2001,276(13):10063-71
5Buddai SK,Toulokhonova L,Bergum PW et al.Nematode anticoagulant Protein c2 reveals a site on factor Xa that is important for macromolecular cubstrate binding to human prothrombinase[J].J Biol Chem,2002,277:26689-98
7Vlasuk GP,Bradbury A,Lopez-Kinninger L et al.Pharmacokinetics and anticoagulant properties of the factor VⅡa-tissue factor inhibitor recombinant Nematode Anticoagulant Protein c2 following subcutaneous administration in man.Dependence on the stoichiometric binding to circulating factor X[J].Thromb Haemost,2003,90(5):803-12
8Vlasuk GP,Bradbury AE,Bergum PW et al.Early clinical evaluation of rNAPc2,a novel inhibitor of blood coagulation factor VⅡa/tissue factor(f VⅡa/TF) [J].J Am Coll Cardiol,1999,33:255-6.
9Freiderich PW,Levi M,Bauer KA et al.Ability of recombinant factor VⅡa to generate thrombin during inhibition of tissue factor in human subjects[J].Circulation.2001,103:2555-9.
10Lee A,Agnelli G,Buller H et al.Dose-reponse study of recombinant factor VⅡa/tissue factor factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement[J].Circulation,2001,104:74-8.
