摘要
经典理论认为糖皮质激素(glucocorticoid,GC)通过调节基因表达发挥其生理药理作用,该过程耗时长,起效慢。然而,越来越多的证据表明GC可在数秒钟或者数分种内完成对神经内分泌、细胞因子释放、能量代谢及机体行为的调节,该效应被称为GC的快速非基因组效应。深入阐明GC非基因组作用机制将有助于指导GC的临床合理用药并减少其不良反应。以下就GC的非基因组效应机制及其在哮喘治疗中的作用展开综述。
It is well know that glucocorticoid（GC） acts via classic genomic mechanisms of slow onset.However,increasing evidence show that GC can regulate neuroendocrine,cytokine releasing,metabolism,and behavior in second or minute.These activities of GC are called rapid non-genomic effects.The further investigation of non-genomic effects will conduce to the rational administration and decrease the side effects of GC in clinical therapy.This review summarizes the non-genomic mechanisms of GC and the therapeutical role in asthma.
出处
《中华哮喘杂志（电子版）》
CAS
2012年第2期56-60,共5页
Chinese Journal of Asthma(Electronic Version)
