摘要
目的比较传统肠道准备与快速肠道准备对结直肠癌患者术后肠道菌群变化的影响。方法前瞻性人组2010年3月至2011年3月间南方医科大学南方医院收治的60例结直肠癌患者，按抓阄的方法随机分成试验组（33例，术前仅行1d的肠道准备）和对照组（27例，按传统的3d方案进行肠道准备）。分别于肠道准备前和术后第1次排粪时，留取粪便进行肠道菌群分析，并观察术后肠道菌群紊乱及感染性并发症的发生情况。结果两组患者术后均发生不同程度的肠道菌群失调，表现为双歧杆菌、乳酸杆菌等益生菌种计数较术前明显减少（P〈0．05），且对照组较试验组下降更明显（P〈0．05）；而大肠杆菌、葡萄球菌等致病菌的计数则明显高于术前（P〈0．05），且对照组明显高于试验组（P〈0．05）。试验组术后感染性并发症发生率为9．1％（3／33），明显低于对照组的29．6％（8／27）（P〈0．05）。结论快速肠道准备在一定程度上可减轻术后肠道菌群的紊乱程度，并降低术后感染性并发症的发生率。
Objective To compare the impact of traditional and fast bowel preparation on the changes of gut flora in the patients following eolorectal resection. Methods Sixty patients undergoing colorectal resection from March 2010 to March 2011 in the Nanfang Hospital were randomly divided into the control group （n=27, 3 days of bowel preparation） and the experimental group （n=33, 1 day of bowel preparation）. Fresh feces were collected before bowel preparation and on the first defecation after surgery. The postoperative changes in gut flora and septic complications were observed. Results Gut flora disturbance was found in both groups. The postoperative population of Bifidobacterium and Lactobacillus decreased significantly（P〈0.05）, and the decrease was more significant in the experimental group compared to the control group （P〈0.05）, while E.coli and Staphylococcus were much higher than the preoperative level （P〈0.05）, which was more significant in the control group. The incidence of postoperative infection was 9.1% （3/33） in the experimental group, which was significantly lower than 29.6%（8/27） in the control group （P〈0.05）. Conclusion Fast bowel preparation is effective in reducing gut flora disturbance and the incidence of postoperative infection.
出处
《中华胃肠外科杂志》
CAS
2012年第6期574-577,共4页
Chinese Journal of Gastrointestinal Surgery
关键词
结直肠肿瘤
肠道准备
肠道菌群
感染并发症
Colorectal neoplasms
Bowel preparation
Intestinal flora
Infectious complications
