摘要
肺炎克雷伯菌已成为院内感染的重要病原菌,且多重耐药菌株不断出现,已经成为临床治疗感染的一大难题。中药凭借自身优点受到广泛关注,其多重抗菌活性为解决病原菌的多重耐药提供了新的思路。文章介绍了肺炎克雷伯菌多重耐药机制、传播机制和具有抗菌作用的中药,从消除耐药质粒、抑制灭活酶和主动外排方面阐述了抗菌中药逆转菌株耐药性的作用,并探讨抗菌中药研究中存在的一些问题,以期为临床用药和抗菌药物的研发提供参考。
Klebsiella pneumoniae has become the important pathogens of nosocomial infection. Broad-spectrum antibacterial consumption is increasing clinically in many countries around the world, and it is increasingly recognized as the major reason for the emergence of resistance. The recent alarming rise of infections caused by antibiotic-resist pathogens, including multidrug resistant kebsiella pneumoniae, has been observed, particularly in intensive care units. Traditional Chinese medicine （TCM） becomes a subject of concern with low resistance and low toxic side effects of the significant advantages. They proved to be active against the Gram-positive and Gram-negative organisms. There is also evidence show that the resistance of K. pneumoniae isolates could be moderately reversed by using TCM to inhibit resistant plasmid, inactived enzyme and active efflux pump. Besides, the combinations of antibiotics and Chinese medicines exhibit active effects. Focusing on the molecular mechanism of bacterial resistance, this paper reviewed the progress in the studies of inhibitor of traditional Chinese medicine to K. pneumoniae in recent years, in order to provide a new approach to clinical medication and new drug research.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2012年第6期1624-1627,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
关键词
肺炎克雷伯菌
多重耐药
中药
Klebsiella pneumoniae
Multidrug resistance
Traditional Chinese medicine
