摘要
制备了β-丙氨酸-银复合膜修饰电极(Ag-Ala/GCE),采用循环伏安法研究了对乙酰氨基酚在修饰电极上的电化学行为。结果表明:在pH 4.0的磷酸盐缓冲液中,对乙酰氨基酚在修饰电极上呈现一对灵敏的氧化还原峰,提出了用循环伏安法测定对乙酰氨基酚的含量。对乙酰氨基酚浓度在6.0×10-7～7.0×10-4 mol.L-1范围内与氧化峰电流呈现线性关系,检出限(3S/N)为2.0×10-7 mol.L-1。修饰电极用于药剂中对乙酰氨基酚的测定,并用标准加入法测得方法的回收率在95.1%～101.6%之间。
The β-alanine and silver composite film modified glassed carbon electrode （Ag-Ala/GCE） was prepared and the electrochemical property of the modified electrode vs. p-acetaminophenol （ACOP） was studied by cyclic voltammetry. It was found that ACOP showed a pair of redox peaks in PBS of pH 4. 0 and based on this finding, a selectrive method for determination of ACOP by cyclic voltammetry was proposed. Linear relationship between values of peak current and concentration of ACOP was ranged from 6.0×10^-7～7.0×10^-4mol·L-1, with detection limit （3S/N） of 2.0×10^-7mol·L-1. The proposed method was used in the determination of ACOP in medicament, and test for recovery was made by standard addition method, giving values of recovery in the range of 95.1%～101.6%
出处
《理化检验（化学分册）》
CAS
CSCD
北大核心
2012年第5期530-533,共4页
Physical Testing and Chemical Analysis(Part B:Chemical Analysis)
基金
山东省高等学校科技计划项目(J10LB64)
山东省自然科学基金资助项目(2R2009BM003)
