摘要
近年研究发现，肿瘤细胞发生上皮向间质转化（EMT）摆脱细胞与细胞间连接而发生转移侵袭，已成为上皮细胞癌转移侵袭以及化疗耐药的一个重要途径。Snail家族成员，尤其是Snail被认为是肿瘤EMT发生的重要调节因子，它可以通过竞争性抑制E一钙黏蛋白基因的表达，引起上皮细胞向间质细胞表型的转变，最终引起EMT。多项研究显示，在消化系统肿瘤中普遍存在EMT现象，并与这些肿瘤的侵袭转移及化疗耐药密切相关。
Recent studies show that tumor cells get rid of the connections between cells, and induce tumor invasion and metastasis through epithelial-mesenchymal transition （EMT）. EMT becomes an important way to invasion, metastasis and chemotherapy resistance of epithelial cell carcinoma which accounting for more than 90% of malignant carcinomas. Members of Snail family, especially Snail is regarded as important adjust- ment factor of EMT, which induce the transformation from epithelial cell to mesenchymal phenotype through competitive inhibition E-calcium protein gene expression. Many researches show that EMT exists widely in digestive system tumors, which is closly related to the invasion, metastasis and chemotherapy resistance of digestive system tumors.
出处
《国际肿瘤学杂志》
CAS
2012年第5期380-383,共4页
Journal of International Oncology
基金
基金项目：国家自然科学基金资助项目（81071816）
关键词
上皮向间充质转化
消化系统肿瘤
糖蛋白类
Epithelial-mesenchymal transition
Digestive system neoplasms
Glycoproteins
