摘要
目的探讨妊娠合并甲状腺功能亢进症孕妇的妊娠结局和预后。方法以50例妊娠合并甲状腺功能亢进症产妇为研究对象,将其中经过正规治疗且产前甲状腺功能基本恢复正常者31例设为研究组1,将19例未经过正规治疗的患者设为研究组2,另外选取35例正常妊娠妇女为对照组。给予研究组患者相应治疗,并对甲状腺功能、妊娠结局和预后进行比较。结果研究组1患者的T3、T4值高于对照组,两组比较差异有统计学意义(P<0.05);研究组2患者的T3、T4、β2-M值显著高于研究组1,两组比较差异有高度统计学意义(P<0.01)。研究组1患者FT3、FT4值明显低于研究组2,而TSH值则高于研究组2,两组间比较,差异有高度统计学意义(P<0.01)。研究组2产妇的心力衰竭、流产、高血压、甲亢危象和新生儿的早产、窒息、死亡的发生率明显高于研究组1和对照组(P<0.05)。研究组1有2例患者出现复发现象,研究组2中6例患者出现原有症状加重,对照组所有产妇均正常。结论妊娠合并甲状腺功能亢进症可给母婴带来严重的危害,早期发现并进行正规治疗,可减低其对母婴的危害,改善妊娠结局。
Objective To investigate the pregnancy outcome and prognosis of pregnant women with hyperthyroidism.Methods 50 cases of pregnant women with hyperthyroidism were selected as the research objects of whom 31 cases of patients who were given formal therapy and prenatal thyroid function back to normal were divided into the study group 1,19 cases of patients who were not given regular treatment were divided into the study group 2,in addition,35 cases of normal pregnant women were selected as the control group.The study groups were given the corresponding treatment,and the thyroid function,pregnancy outcome and prognosis were compared.Results The values of T3,T4 in the study group 1 were higher than those in the control group,the differences were statistically significant（P 0.05）;The values of T3,T4 and β2-M in the study group 2 were significantly higher than those in the study group 1,the differences were statistically significant（P 0.01）.The values of FT3,FT4 in the study group 1 were obviously lower than those in the study group 2,but the TSH value was higher than that in the study group 2,the differences were statistically significant（P 0.01）.The incidence of parturient heart rate failure,abortion,high blood pressure,hyperthyroidism crises and neonatal premature delivery,asphyxia,death in the study group 2 were higher than those in the study group 1 and the control group（P 0.05）.In the study group 1,2 patients appeared recurrent phenomenon,in the study group 2 6 patients appeared original symptom aggravating,parturient of the control group were all normal.Conclusion Pregnancy combined with hyperthyroidism can bring serious harm for mothers and infants,early detection and giving regular treatment can reduce the harm of mothers and infants,improve the pregnancy outcome.
出处
《中国医药导报》
CAS
2012年第17期68-69,72,共3页
China Medical Herald
