摘要
目的探讨薯莨鞣质和五倍子鞣质对辐射损伤的防护作用。方法 40只雄性昆明种小鼠,随机分为空白对照组、单纯照射组、茶多酚组(阳性对照组)、五倍子鞣质组和薯莨鞣质组。给予单次8.0 Gy 60Coγ射线照射(剂量率2.0 Gy/min),照前2h及照后18h分别各灌胃给药一次,测定30d存活率、平均存活时间及保护系数等,空白对照组佯照射。结果单纯照射组小鼠照后16d内全部死亡,平均存活时间(12.0±2.45)d。薯莨鞣质组、五倍子鞣质组和茶多酚组小鼠的平均存活时间分别为(26.25±7.13)d(、21.88±8.89)d和(23.25±9.33)d,与单纯照射组相比生存时间明显延长(P<0.01或P<0.05)。结论薯莨鞣质和五倍子鞣质可提高8.0 Gy 60Coγ射线照射小鼠30天存活率,对γ射线辐射损伤具有防护作用。
Objective To explore the protective effect of tannins from Dioscoreae Cirrhosae and Galla chinensis on radiation injury. Methods Forty male Chinese Kunming mice were randomly divided into non - radiation group, radiation group without drugs, radiation group with tea polyphenols, radiation group with tannins from Dioscoreae Cirrhosae and radiation group with tannins from Galla chinensis. The radiation groups were irradiated with a single exposure Of 8.0 Gy ＂y rays from 6~Co. The mice were intragastrically administered 2 h before radiation and were done 18 h after radiation. The 30 -day survival rate, the mean survival time and the protective coefficients were confirmed. Results All the mice of radiation group without drugs died in 16 d after exposure, and their mean survival time was （12.0 ± 2.45 ） d, while the radiation groups with tannins from Dioscoreae Cirrhosae, with tannins from Galla chinensis and with tea polyphenols were （26.25 ± 7.13） d, （21.88 ± 8.89 ） d and （23.25 ± 9.33 ） d respectively. There was significant difference in comparison with radiation group without drugs （ P 〈 0.05 or P 〈 0.05）. Conclusion The tannins from Dioscoreae Cirrhosae and Galla chinensis could lengthen the mean survival time of mice exposed to 8.0 Gy γ rays from 60 Co and could present a significant protection effect on radiation injuries.
出处
《中国辐射卫生》
2012年第2期139-140,共2页
Chinese Journal of Radiological Health
基金
上海市科委基金资助项目(No.09411961200)
关键词
鞣质
急性放射损伤
存活率
小鼠
Γ射线
Tannin
Acute Radiation Injury
Livability
Mouse
Gamma Ray
