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阿托伐他汀联合依折麦布对糖尿病患者内皮功能及炎症指标的影响 被引量：8

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摘要 目的探讨应用阿托伐他汀联合依折麦布与单用阿托伐他汀强化降脂对糖尿病患者血脂,内皮功能及炎症指标的影响。方法确诊的糖尿病患者同时具有高脂血症患者102例。其中51例采用饮食控制加阿托伐他汀20mg联合依折麦布10mg治疗6周,对照组采用采用饮食控制加阿托伐他汀40mg,6周后比较2组之间血脂、内皮功能及炎症指标。结果采用阿托伐他汀联合依折麦布治疗组血脂降低明显(t=2.12,P=0.041),且阿托伐他汀联合依折麦布组较阿托伐他汀组降低CRP(t=4.34,P=0.005)。但单用阿托伐他汀组一氧化氮(NO)水平及FMD较阿托伐他汀联合依折麦布组改善明显(t=-2.2,P=0.056;t=-3.12,P=0.03)有统计学意义。结论虽然阿托伐他汀联合依折麦布较阿托伐他汀更降低高脂血症及炎症反应,但是阿托伐他汀组更改善血管内皮功能。
作者 肖四海 宋巧凤 刘春荣 王小玲
机构地区 河北省唐山市人民医院心内科
出处 《河北医药》 CAS 2012年第11期1650-1652,共3页 Hebei Medical Journal
关键词 高脂血症 阿托伐他汀联合依折麦布 血流依赖性舒张功能 一氧化氮 C-反应蛋白
分类号 R587.1 [医药卫生—内分泌]
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参考文献6

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共引文献37

同被引文献83

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引证文献8

二级引证文献83

河北医药
2012年 第11期

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