摘要
目的研究雷公藤内酯醇生物贴的体外经皮吸收特点。方法利用改良Franz扩散池研究雷公藤内酯醇生物贴的经皮吸收特点,以HPLC法测定雷公藤内酯醇的经皮吸收量。结果雷公藤内酯醇生物贴中的雷公藤内酯醇在24h内以一级动力学经皮渗透,累积渗透量为2.0573μg/cm2。结论雷公藤内酯醇生物贴中雷公藤内酯醇的体外透皮吸收效果优于文献报道的巴布剂。
Objective To study the percutaneous absorption characteristic of triptolide biological patch in vitro.Methods Franz diffusion cell was used to study the percutaneous absorption characteristic of triptolide biological patch,and HPLC was used to determinate the percutaneous absorption amount of triptolide.Results The percutaneous penetration of triptolide in 24 h was consistent with first-order kinetic model and the cumulative release in 24 h was 2.057 3 μg/cm2.Conclusion The transdermal characteristics in vitro of triptolide biological cataplasma is better than plaster reported in the literature.
出处
《现代药物与临床》
CAS
2012年第3期236-238,共3页
Drugs & Clinic
基金
福建省科技重大专项(2009YZ0001-1-3)
福建省医学创新项目(2009-CX-16)
福建省省属公益类科研院所基本科研专项(2011R1034-3)
