摘要
目的:分析2型糖尿病(type 2 diabetes,T2DM)患者并发骨质疏松症后骨密度(bone mineral density,BMD)的改变及其与各种危险因素的相关性,为早期诊断、早期防治糖尿病并发骨质疏松症提供理论依据。方法:根据受试者的骨密度值将糖尿病患者分为骨质疏松组(OP组)和非骨质疏松组(非OP组),对比两组T2DM患者的性别、年龄、体质量指数(body mass index,BMI)、糖尿病病程、空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(postprandial blood glucose,PBG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL)、三酰甘油(triglycerides,TG)、血清钙、磷、镁、碱性磷酸酶(alkaline phosphatase,ALP)和尿酸之间的差异,并进行相关性分析。结果:OP组与非OP组比较,年龄大、病程长、骨密度低、血磷高,两组间差异均有统计学意义(P<0.05)。T2DM患者的BMD与年龄、病程、ALP、HbA1c呈负相关,与BMI呈正相关;与空腹血糖、餐后2 h血糖、TG、LDL、血钙、血磷、血镁、尿酸无相关性。结论:高龄、低体质量、病程长、血糖控制差、高血ALP,都是糖尿病合并骨质疏松症的危险因素。
Objective： To analyze the changes of bone mineral density（BMD） in type 2 diabetes（T2DM） patients and the correlation of risk factors,so as to provide arly diagnosis and prevention of diabetes complicated by osteoporosis.Methods： The patiants with T2DM was devided to osteoporosis group and non-osteoporosis group,accorrding to BMD values.Compare the following risk factors of two groups： sex,age,body mass index（BMI）,duration of diabetes,fasting glucose,postprandial 2h blood glucose,glycosylated hemoglobin（HbA1c）,low-density lipoprotein cholesterol（LDL）,triglycerides,lipoprotein,serum calcium,phosphorus,magnesium,alkaline phosphatase（ALP） and uric acid,and analyze the correlation between the above risk factors with BMD in T2DM complicated by osteoporosis.Results： Fasting blood glucose（FBG）,postprandial blood glucose（PBG）,HbA1c was significantly increased.T2DM with BMD and age,disease duration,the ALP was negatively correlated,with BMI was positively correlated,with fasting blood glucose,2 h postprandial blood glucose,triglycerides,LDL,serum calcium,phosphorus,serum magnesium and uric acid was no correlation.Conclusion： The older age,low weight,long duration,poor blood glucose,high blood alkaline phosphatase were all the risk factors of diabetic patients with osteoporosis
出处
《南通大学学报（医学版）》
2012年第3期196-198,共3页
Journal of Nantong University(Medical sciences)
关键词
2型糖尿病
骨密度
骨质疏松症
危险因素
相关性
type 2 diabetes
bone mineral density
osteoporosis
risk factors
correlation
