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西藏林芝地区间日疟原虫PvMSP-3α基因多态性研究 被引量：1

Allelic polymorphism in the merozoite surface protein-3α of Plasmodium vivaxin Linzhi Prefecture of Tibet
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摘要 目的分析西藏林芝地区间日疟原虫遗传多态性。方法以间日疟原虫裂殖子表面蛋白3α(Plasmodium vivax merozoite surface protein-3α,PvMSP-3α)为分子标志,利用PCR-RFLP技术对西藏林芝地区间日疟原虫多态性进行分析。结果共发现2种类型的MSP-3α基因,多数为A型(90.3%),B型较少(9.7%),无混合感染。PCR-RFLP分析MSP-3α基因存在较低多态性。结论西藏林芝地区间日疟原虫的遗传多态性较低。 With PCR-RFLP amplification method,allelic polymorphism was analyzed in merozoite surface protein genes-3α（PvMSP-3α）of Plasmodium vivax（P.vivax） to study the genetic diversity of PvMSP-3α in Linzhi Prefecture of Tibet.Results showed that two different sizes of MSP-3α gene were found in this area（type A is 1.9 kb,90.3%;and type B is 1.5 kb,9.7%）,and no mixture infection was detected.The MSP-3α gene exhibited low polymorphism in PCR-RFLP analysis,indicating that the genetic diversity of P.vivax in Linzhi Prefecture of Tibet is in a low degree.
作者 李军伟 周水森 黄芳
机构地区 中国疾病预防控制中心寄生虫病预防控制所
出处 《中国人兽共患病学报》 CAS CSCD 北大核心 2012年第6期536-538,共3页 Chinese Journal of Zoonoses
基金 中国/WHO2010-2011年合作项目(No.CHN188-11) 卫生部卫生行业科研专项项目(200802021)联合资助~~
关键词 间日疟原虫 遗传多态性 PvMSP-3α Plasmodium vivax genetic diversity PvMSP-3α
分类号 R382.3 [医药卫生—医学寄生虫学]
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参考文献10

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共引文献25

同被引文献34

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中国人兽共患病学报
2012年 第6期

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