摘要
用酒石酸衍生物O,O’-二苯甲酰基酒石酸(DBTA)代替有机胺类化合物,通过金属配合拆分方法有效地拆分邻氯扁桃酸。研究了拆分溶剂体系、固体析出方式、主客体比对拆分效率的影响,建立了在"绿色溶剂"水为主要溶剂条件下,添加适量的异丙醇,搅拌析出的最佳工艺条件。实验结果表明,主客体比n(DBTA与CaO)∶n(邻氯扁桃酸)为1∶1,2.5mmol邻氯扁桃酸在6mL水和4mL异丙醇溶剂体系下,拆分效率可达到58.5%。
O,O＇-Dibenzoyltartaric acid （DBTA） prepared from tartaric acid could substitute chiral amines for the coordination-mediated resolution of racemic 2-chloromandelic acid. The effects of solvent system, solid preciptation method and ratio of host and guest on the resolution of 2-chloromandelic acid were studied. The best resolution efficiency was obtained when the ratio of host and guest was 1 ： 1 in the mixture of ＂green solvent＂ water and isopropyl alcohol. The results showed that 2.5mmol racemic 2- chloromandelic acid was efficiently resoluted in 6 mL water and 4 mL isopropyl alcohol through cooling by stirring. Under the optimum conditions, the resolution efficiency could reach 58.5%.
出处
《化学世界》
CAS
CSCD
北大核心
2012年第6期364-367,共4页
Chemical World
基金
江西省科技厅科技计划项目(2010BSA18700)
江西省卫生厅科技计划项目(20092044)
关键词
邻氯扁桃酸
金属配合拆分
绿色手性拆分
2-chloromandelic acid
coordination-mediated resolution
green chiral resolution
