摘要
目的检测基质金属蛋白酶-9(MMP-9)和血管内皮生长因子(VEGF)在非小细胞肺癌组织中的表达,并评估其预后价值。方法应用免疫组织化学技术检测86例非小细胞肺癌和60例正常肺组织中MMP-9和VEGF的表达,分析其在不同临床特征中的价值,关注其表达对判断预后的意义。结果非小细胞肺癌中MMP-9和VEGF表达的阳性率明显高于正常肺组织,MMP-9和VEGF的表达与非小细胞肺癌肿瘤的直径、胸膜侵犯、分化程度及淋巴结转移有关,非小细胞肺癌中MMP-9和VEGF的表达呈正相关,生存分析显示MMP-9和VEGF的表达与患者的预后有关。结论非小细胞肺癌中MMP-9和VEGF高表达,MMP-9可能对肿瘤的血管形成有促进作用,联合检测MMP-9和VEGF的表达可能与非小细胞肺癌患者的预后有关。
Objective To investigate the protein expressions of MMP-9 and VEGF, observe their relationship and clinical significance on development and metastasis of non-small cell lung carcinoma. Methods We detected the protein expres- sions of MMP-9 and VEGF by IHC in the non-small cell lung carcinoma （86 cases） and normal lung tissues （60 cases）. Their expression relationship and different pathological characters in the non-small cell lung carcinoma were analyzed. Results The protein expressions of MMP-9 and VEGF were higher in the neoplasm than in normal lung tissues. Their ex- pressions were correlated with diameter, pleura invasion, differentiation and lymph node metastasis. Positive correlation between MMP-9 and VEGF protein were found in neoplasm. The expressions of MMP-9 and VEGF were correlated with prognosis. Conclusion The higher expressions of MMP-9 and VEGF are found in non-small cell lung carcinoma. The combined detection of MMP-9 and VEGF may be helpful for prognosis of neoplasm.
出处
《中国现代医生》
2012年第16期58-59,62,共3页
China Modern Doctor
