摘要
目的：探讨川芎嗪对慢性低Ｏ２高ＣＯ２大鼠肺动脉压力及肺动脉管壁胶原的影响。方法：将ＳＤ大鼠３０只分为：对照组（Ａ），低Ｏ２高ＣＯ２组（Ｂ），低Ｏ２高ＣＯ２＋川等嗪组（Ｃ），低Ｏ２高ＣＯ２时间为４周。结果：（１）Ｂ组肺动脉平均压（ｍＰＡＰ）显著高于Ａ组（Ｐ＜０．０１），Ｃ组ｍＰＡＰ显著低于Ｂ组（Ｐ＜０．０１），３组间平均颈动脉压无显著差异（Ｐ＞０．０５）；（２）电镜显示Ｂ组肺动脉胶原纤维较Ａ组明显为多，Ｃ组较Ｂ组明显为少。免疫组化显示Ｂ组肺动脉Ⅰ型胶原含量（平均吸光度值ＬＤ）较Ａ组明显为高（Ｐ＜０．０１），Ｃ组较Ｂ组明显为低（Ｐ＜０．０１），Ⅲ型胶原ＬＤ各组间无明显差异（Ｐ＞０．０５）；（３）Ｂ组血浆内皮素浓度高于Ａ组，血清ＮＯ－２／ＮＯ－３低于Ａ组，Ｃ组血浆内皮素浓度低于Ｂ组，ＮＯ２－／ＮＯ３－高于Ｂ组，Ｐ均＜０．０１。结论：川芎嗪可预防慢性低Ｏ２高ＣＯ２性肺动脉高压的形成和肺动脉管壁胶原的沉积。
AIM: To study the effect of ligustrazine on pulmonary hypertensive rats induced by hypoxic hy- percapnia. METHODS: Thirty rats were randomly divided into three groups: control group(A), hypoxic hypercapnic group (B), hypoxic hypercapnia+ligustrazine (lig. ) group(C). RESULTS: (1) Mean pulmonary axterial pressure (mPAP)of group B was significantly higher than that of group A and mPAP of group C was significantly lower than that of group B(P<0.01), differences of main carotid pressure (mCAP) were not significant among three groups (P >0.05); (2)Electron microscopy and immunohistochemistry showed ligustrazing could inhibit the diposition of col- lagenous fiber(collagen type Ⅰ )in pulmonary arterioles induced by hypoxic hypercapnia; (3) Plasma endothelin level of group C was significantly lower than that of group B (P<0.01 ), serum (NO2- /NO3-) of group C was significantly higher than that of group B (P < 0.01 ). CONCLUSION: Ligustrazine can inhibit pulmonary hypertension and the diposition of collagen type Ⅰ in pulmonary alienal wall induced by hypoxic hypercapnia.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2000年第5期436-439,共4页
Chinese Journal of Pathophysiology
关键词
低氧
高碳酸血
肺动脉高压
川芎嗪
大鼠
Drugs
Chinese herbal
Anoxia
Hypercapnia
Hypertension
pulmonary
Collagen
