摘要
目的:了解山西省常见的乙型肝炎病毒(HBV)基因型,探讨HBV各基因型与血清HBV-DNA水平以及疾病进展的临床意义。方法:随机收集山西省HBV DNA阳性病例680例进行基因分型,并结合临床资料进行统计学分析。结果:680例HBV感染者中,有65例(9.6%)未测出基因型。在可检出基因型的615例患者中,基因型B、C、B/C分别占8.9%、82.6%、8.5%。C型、B/C型的HBV DNA载量明显高于B型(P<0.05);各基因型与肝病的严重程度间差异有显著性意义(P<0.05)。结论:山西省HBV基因型中以C型为优势,其次为B/C和B型。基因C型和B/C型在慢性重型肝炎中较为常见,基因C型更易发生肝硬化和肝癌。
Objective： To examine the geographic distribution of hepatitis B virus （HBV） genotypes in Shanxi province and to evaluate the relationship of HBV DNA viral load and progression .of HBV infection with HBV genotypes. Methods： Six hun- dred and eighty patients with positive HBV DNA from Shanxi province were randomly collected and analyzed according to the clin- ical data.Results： In this study, genotypes B, C, B/C accounted for 8.9% , 82.6% , 8.5% , respectively in 615 inspected patients, while 9.6% was not found in 680 HBV-infected patients. The HBV DNA viral load for genotype C and B/C was signifi- cantly higher than genotype B in patients （P 〈 0. 05 ） . The statistical significant differences of genotypes and severity of the liver diseases were also observed （P 〈 0.05 ） . Conclusion： Over all, genotype C is the most prevalent followed by B/C and B in Shanxi Province. And there were more genotype C and B/C in chronic severe hepatitis. CHB patients with genotype C have a higher tendency to develop hepatic cirrhosis and carcinoma.
出处
《中西医结合肝病杂志》
CAS
2012年第3期170-171,175,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
山西省青年科技研究基金资助项目(No.2011021037-1)
山西省中医药研究院院级课题资助(No.201005)
关键词
肝炎
乙型
慢性
基因型
分布特点
临床意义
hepatitis B virus
genotype
distribution
clinical significance
