期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

定量检测降钙素原在患者感染诊断及其预后判断中的临床价值 被引量：24

Clinical significance of procalcitonin quantitative detection for diagnosis and prognosis of infections in patients
在线阅读 下载PDF
导出
摘要 目的探讨血清降钙素原(procacitonin,PCT)对患者感染诊断及其预后判断的临床价值。方法对某院2009年9月—2010年12月同时采集血液进行细菌培养与PCT检测患者的临床资料进行回顾性分析。结果 570份同时送检的标本,PCT和血培养的阳性率分别为46.49%(265/570)、30.18%(172/570);以0.50 ng/mL为界点,PCT诊断的敏感性为90.53%(516/570)、特异性为64.74%(369/570),阳性预测值和阴性预测值分别为44.53%(118/265)、82.30%(251/305)。结论定量PCT检测对患者早期感染的诊断及预后判断具有重要的指导意义,可连续监测患者感染状况,及时为临床决策提供依据。 Objective To evaluate the clinical significance of procalcitonin （PCT） for the diagnosis and prognosis of infections in patients. Methods PCT and blood culture data of patients in a hospital from September 2009 to December 2010 were analyzed retrospectively. Results Among 570 detected samples, the positive rate of PCT and blood culture was 46. 49% （265/570） and 30. 18% （172/570） respectively; when PCT = 0. 50ng/mL was used as the cut-off value of diagnosis, the sensitivity and specificity of PCT was 90. 53%（516/570）and 64. 74% （369/570） respectively, the positive and negative predictive value of PCT was 44. 53% （118/265）and 82. 30% （251/305） re- spectively. Conclusion Quantitative PCT has important guiding significance for the early diagnosis and prognosis e- valuation of infections in patients, it can provide evidence for clinical decision-making by continuously monitoring in- fections in patients.
作者 蒋伟 李少增 周峥
机构地区 解放军总医院附属第一医院
出处 《中国感染控制杂志》 CAS 2012年第3期189-191,共3页 Chinese Journal of Infection Control
关键词 降钙素原 感染 诊断 预后 病原菌 血培养 procalcitonin infectiom diagnosis prognosis pathogenl blood culture
分类号 R446 [医药卫生—诊断学]
  • 相关文献

参考文献7

  • 1Assicot M,Gendrel D,Carsin H,et al. High serum procalcito- nin concentrations in patients with sepsis and infection[J]. Lancet, 1993, 341(8844) :515 - 518.
  • 2Becker K L, Snider R, Nylen E S. Procalcitonin assay in sys- temic inflammation, infection, and sepsis: clinical utility and limitations[J]. Crit Care Med, 2008, 36(3) :941 - 952.
  • 3Ferriere F. Procalcitonin, a new marker for bacterial infections [J]. Ann Biol Clin(Pairs), 2000, 58(1) :49- 59.
  • 4Schuetz P, Mueller B, Trampuz A. Serum procalcitonin for discrimination of blood contamination from bloodstream infec- tion due to coagulase-negative staphylococci [J]. Infection, 2007, 35(5) :352 - 355.
  • 5Reith H B, Mittelkotter U, Wagner R, et al. Procalcitonin (PCT) in patients with abdominal sepsis[J]. Intensive Care Med,2000,26(Suppl 2) : S165 - S169.
  • 6张有江,王欢,罗燕萍,刘朝军,陈荣,赵强,刘冰,王晓宁.定量降钙素原测定在血流感染诊断中的应用[J].军医进修学院学报,2010,31(12):1219-1221. 被引量：32
  • 7Schultz M J,Deterrnann R M. PCT and sTREM-1 :The mark- ers of infection in critically ill patients ? [J]. Med Sci Monk, 2008, 14(12):241 - 247.

二级参考文献11

  • 1Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States : analysis of incidence, outcome, and associated costs of care [ J ] . Crit Care Med, 2001, 29 ( 7 ) : 1303-1310.
  • 2Dombrovskiy VY, Martin AA, Sunderram J, et al. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States : a trend analysis from 1993 to 2003 [ J ]. Crit Care Med, 2007, 35 ( 5 ) : 1244-1250.
  • 3Aikawa N, Fujishima S, Endo S, et al. Muhicenter prospective study of procalcitonin as an indicator of sepsis [ J ] . J Infect Chemother, 2005, 11 (3) : 152-159.
  • 4Reith HB, Mittelkotter U, Wagner R, et al. Procaleitonin (PCT) in patients with abdominal sepsis [ J ] . Intensive Care Med, 2000, 26 Suppl 2 : S165-S169.
  • 5Schuetz P, Mueller B, Trampuz A. Serum procalcitonin for discrimination of blood contamination from bloodstream infection due to coagulase-negative staphylococci [ J ] . Infection, 2007, 35 ( 5 ): 352-355.
  • 6Assicot M, Gendrel D, Carsin H, et al. High serum procalcitonin eoncentralions in patients with sepsis and infection [ J 1 . Lancet, 1993, 341 ( 8844 ) : 515-518.
  • 7Ferri e re F. Procaicitonin ,a new marker for bacterial infections [ J ].Ann Biol Clin (Paris), 2000, 58 ( 1 ) : 49-59.
  • 8Meisner M, Tschaikowsky K, Schmidt J, et al. Procalcitonin (PCT)-Indications for a new diagnostic parameter of severe bacterial infection and sepsis in transplantation, immunosupprcssion and cardiac assist devices [ J ] . Cardiovasc Eng, 1996, 1 : 67-76.
  • 9Sponholz C, Sakr Y, Reinhart K, et al. Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery : a systematic review of the literature [ J ] . Crit Care, 2006, 10 ( 5 ): R145.
  • 10Uzzan B, Cohen R, Nicolas P, et al. Procalcitonln as a diagnostic test for sepsis in critically ill adults and after surgery or trauma : a systematic review and meta-analysis [ J ] . Crit Care Med, 2006, 34 ( 7 ) : 1996-2003.

共引文献31

同被引文献191

引证文献24

二级引证文献226

中国感染控制杂志
2012年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部