摘要
目的研究血清维生素D与2型糖尿病的关系。方法对乌鲁木齐市水磨沟区糖尿病高危人群(569名)进行口服葡萄糖耐量试验(OGTT),取数据完整的555名受试者,按照1999年世界卫生组织(WHO)糖尿病的诊断标准分为2型糖尿病组和正常糖代谢的对照组,比较两组间血糖、血脂、血压、血清维生素D等指标的差异,并对血清维生素D与上述指标进行相关性分析。结果 2型糖尿病组的空腹血糖(FPG)、餐后2h血糖(2hPG)、按HO-MA模型估计的胰岛素抵抗指数(HOMA-IR)均明显高于对照组,差异有统计学意义(P<0.05);2型糖尿病组的血清25(OH)D3、按HOMA模型估计的β细胞功能指数(HOMA-IS)均明显低于对照组,差异有统计学意义(P<0.05)。血清25(OH)D3与收缩压(SBP)、FPG、2hPG均呈负相关(P<0.05),与HOMA-IS呈正相关(P<0.05)。结论血清维生素D可能通过直接或间接作用影响胰岛β细胞功能,导致血糖升高。
Objective To investigate the relationship of serum vitamin D and type 2 diabetes mellitus. Methods Di- vided the high risk group （569 subjects） of diabetic mellitus into the type 2 diabetic mellitus and the control groups by the diag- nostic criteria of diabetic mellitus of 1999, and 555 subjects with complete data were analyzed in this study. To compare each in- dicator of the survey and analyze the aasociativity of the serum vitamin D and blood glucose, blood fat, blood pressure and so on. Results The level of FPG, 2hPG, HOMA - IR in the type 2 diabetic mellitus group were higher than that in the control group （ P 〈 0. 05 ）, while serum 25 （OH） D3 and HOMA - IS were lower than that in the control group （ P 〈 0. 05 ） ; There was posi- tive correlation between serum 25 （OH） D3 and HOMA - IS （p 〈 0. 05）, the negative correlations between serum 25 （OH） D3 and SBP、 FPG, 2hPG （P 〈0. 05）. Conclusion Serum vitamin D may influence the function of β -cell through direct or indirect effects, leading to hyperglycemia.
出处
《临床合理用药杂志》
2012年第21期3-5,共3页
Chinese Journal of Clinical Rational Drug Use
基金
新疆维吾尔自治区重点学科(内科学)
关键词
维生素D
糖尿病
2型
血糖
Vitamin D
Diabetes mellitus, type 2
Blood glucose
