摘要
近年来的证据表明，产前感染和炎症是导致早产儿支气管肺发育不良的最主要原因。早产儿的肺脏仍处于发育当中，产前感染使胎肺提早暴露于较高的炎症因子中，对肺部造成损伤，且早产儿由于自身免疫系统尚未发育完善，故不能有效地下调并控制炎症过程，使炎症持续并扩大化，随之使肺发育过程中的一些重要生长因子出现异常，导致肺部微血管发育异常及肺泡化受阻，最终使肺发育停滞，从而形成支气管肺发育不良。
In recent years a body of data has accumulated,linking preterm bronchopulmonary dysplasia （BPD） to prenatal infections and inflammations. The lungs of preterms are still in development. Fetal lungs with intrauterine infections are exposed to high levels of inflammation factors ahead of time, which does harms to lungs. The immune systems of preterms are so immature that they can not effectively down-regulate and control the inflammation process, which exaggerates the inflammation process and causes the abnormal levels of some important growth factors during lung development. As a result, the lung undergoes an dysmorphic microvasculature and disrupted alveolarization, which leads to BPD eventually because of the stagnancy of lung developing.
出处
《国际儿科学杂志》
2012年第4期337-341,共5页
International Journal of Pediatrics
关键词
产前感染
炎症
细胞因子
早产儿
支气管肺发育不良
Intra-uterine infection
Inflammation
Cytokines
Preterm
Bronchopulmonary dysplasia
