摘要
目的探讨有胎儿生长受限（VGR）高危因素的孕妇孕早期使用低分子肝素预防FGR的临床疗效。方法100例孕妇分为观察组60例、对照组40组，均给予维生素E、叶酸每天口服1次，持续至妊娠12周。观察组若D-二聚体检查结果正常则加用低分子肝素5000U每天皮下注射1次，持续至妊娠12周。D-二聚体检查结果异常者调整低分子肝素用量使其结果降至正常。比较两组妊娠结局。结果观察组分娩孕周、新生儿出生体质量、胎盘重量显著高于对照组（t=4．55、2．79、11．91，均P〈0．05），FGR、羊水过少、胎儿窘迫、妊娠期高血压疾病的发生率显著低于对照组（x2=6．50、20．55、7．87、3．76，均P〈0．05）；两组宫内死胎、新生儿窒息、围产儿死亡的发生率差异均无统计学意义（均P〉0．05）。结论有FGR高危因素的孕妇孕早期使用低分子肝素可有效预防和改善FGR，改善妊娠不良结局。
Objective To study the clinical effect of low molecular weight heparin on fetal growth restriction （FGR） prevention in early pregnancy. Methods 100 pregnant women had been employed in our study,they were di- vided into two groups, observation（ n = 60） and control（ n = 40） group. Both groups were given the natural vitamin E 0. lg,and folie acid 0.4rag daily oral administration, continuing to 12 weeks of gestation. 5000 u of subcutaneous dalteparin sodium was added to pregnant women with normal level of D-dimer in the observation group until 12 weeks of pregnancy ,while the dose of Fragmin was adjusted in pregnant women with abnormal level of D-dimer until returned to normal level. The pregnacy outcome of two groups were compared. Results The gestational age, birth weight, pla- cental weight of the obseruation group was significantly higher than thai of the control group （ t = 4.55,2.79,11.91, all P 〈 0.05 ）, while FGR, oligohydramnios, fetal distress and the incidence of hypertensive disorders of the obseruation group were significantly lower than that of control group（ x2 = 6.50,20.55,7.87,3.76, all P 〈 0.05 ） ; Compared to the control group, the observation group didn＇t have higher incidence of intrauterine fetal death, neonatal asphyxia and perinatal death （ P 〉 O. 05 ）. Conclusion Low molecular weight heparin using in early pregnancy was effective in pre- venting FGR in pregnant women with FGR risk factors.
出处
《中国基层医药》
CAS
2012年第13期1956-1957,共2页
Chinese Journal of Primary Medicine and Pharmacy
