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沙利度胺合并环磷酰胺的抗肿瘤作用及相关作用的机制研究 被引量:3

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摘要 目的研究沙利度胺合并环磷酰胺的抗肿瘤作用及机制。方法培养XB1279人结肠癌细胞,给予沙利度胺、环磷酰胺处理后进行荧光定量PCR和MTT检测。结果沙利度胺能抑制VEGFA的表达、促进sFlt-1的表达且具有剂量效应,环磷酰胺能抑制细胞活力且具有剂量效应。结论沙利度胺能够抑制肿瘤血管生长的过程,环磷酰胺能够直接抑制肿瘤细胞的增殖过程,两种药物联合使用能发挥抗肿瘤作用。
作者 施倩
出处 《中国医药指南》 2012年第19期292-293,共2页 Guide of China Medicine
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