摘要
目的:探讨首发精神分裂症患者血清甲状腺激素的变化及相关影响因素。方法:采用化学免疫发光法检测135例首发精神分裂症患者和100例健康对照组的血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)的水平。同时收集患者的一般资料,进行阳性症状量表(SAPS)、阴性症状量表(SANS)的评定。结果:①病例组的血清FT4水平(17.87±3.07 pmol/L)高于对照组(15.96±2.77 pmol/L),差异具有统计学意义(t=4.773,P=0.000)。②病例组不同病程和不同临床分型患者的血清FT3、FT4和TSH水平的差异均无统计学意义(P>0.05)。结论:首发精神分裂症患者存在血清甲状腺激素水平紊乱,与病程、临床症状关系不大,可能是素质指标。
Objective：To explore the changes of thyroid function in patients with first-onset schizophrenia patients and the related factors.Methods：135 cases with schizophrenia（schizophrenia group） and 100 healthy subjects（control group） were recruited for the research.Thyroid functions（FT3,FT4,TSH） were tested by chemiluminescence immunoassay.Schizophrenia group was tested by the self-made general condition questionnaire,the assessment of positive symptoms（SAPS）,the assessment of negative symptoms（SANS）.Results： 1.The level of FT4 in the schizophrenia group（17.87±3.07 pmol/L）was higher than that of the control group（15.96±2.77 pmol/L）（t =4.773,P=0.000）.2.There were no difference about the different courses and different clinical subtypes in the schizophrenia group（P0.05）.Conclusion： Thyroid functions of patients with first-onset schizophrenia were disturbed,without relationship with course and clinical signs,it may be quality mark.
出处
《中国卫生检验杂志》
北大核心
2012年第7期1606-1607,1610,共3页
Chinese Journal of Health Laboratory Technology
基金
2010年广东省科学技术项目(2010B031600311)
