摘要
目的探讨奥曲肽在婴幼儿心胸术后乳糜胸的临床疗效。方法回顾性分析2003年7月至2011年11月间心胸手术后并发乳糜胸15例临床资料，15例分为对照组（9例）和奥曲肽组（6例），两组病例的年龄、体重、术后发生乳糜胸时间等一般资料问差异无统计学意义，乳糜胸的诊断标准一致。分析比较两组病例治疗前、治疗中乳糜胸引流量的变化、治愈时间等数据。两组的数据用均数及标准差（x±s）表示，组间比较采用成组设计资料的t检验，组内比较采用配对t检验，P〈0．05（或P〈0．01）差异有统计学意义。结果对照组胸引流量在治疗后72h[（214．4±130．2）ml／d]、1周[（155．5±86．7）ml／d]较治疗前[（256．6±125．2）ml／d]明显减少（t=5．041，4．623；P=0．001，0．002）。对照组胸引流量治疗后2周[（142．3±120．3）ml／d]、3周[（139．4±113．4）ml／d]较治疗前无明显减少（t=2．099，1．745；P=0．069，0．119）。对照组有3例保守治疗无效，其中2例手术治疗，1例死亡。奥曲肽组6例保守治疗成功。胸引流量在治疗后72hi〈88．3±22．2）ml／d]、1周[（51．2±16．7）ml／d]、2周[（19．3±6．05）ml／d]较治疗前明显减少（t=5．227，5．549，6．638；P=0．003，0．003，0．002）。两组胸引流量在治疗72h、1周、2周间差异有统计学意义（t=2．453，2．900，2．412；P=0．029，0．012，0．031）。两组保守治愈病例术后痊愈时间[对照组（32．8±0．75）d；奥曲肽组（25．2±1．78）d]差异有统计学意义（f=2．512；P=0．028）。结论奥曲肽的使用能明显促进婴幼儿术后乳糜胸恢复，应积极使用。
Objective To investigate the therapeutic efficacy of octreotide for chylothorax after cardiothoracic surgery in infants and young children. Methods Retrospective analysis of 15 post-operative chylothorax cases from July 2003 to November 2011 was done. The cases were divided into control group （n = 9） and octreotide group （n = 6）. There was no significant difference in age, weight, time of occurrence of chylothorax between the 2 groups. The volume of chyle, the healing time and other data were analysed. Data were presented asmean differences and standard deviation （x± s）. Paired t-test was used to analysis difference between two groups and within each group. P〈0. 05（or P〈0. 01）was taken as statistically significant. Results Chyle volume of control groupdecreasedin the post treatment period after 72 hours （214. 4 ± 130. 2 ml/d） and l week （155.5 ± 86. 7 ml/d）when compared to pre- treatment level （256. 6 ± 125.2 ml/d）[t = 5. 041,4. 623;P = 0. 001,0. 002]. But this did not reduce fur- therafter 2 and 3 weeks （142. 3 ± 120. 3 ml/d and 139.4 ± 113. 4 ml/dresectively）. （t = 2. 099,1. 745;P = （/. （169,0. 119）. Treatment failure was seen in 3 cases. 2 cases underwent surgical treatment and 1 case died. All 6 cases in the octreotide grouprecovered after expectant treatment . The chyle volume reduced significantlypost-treatment from 72 h （88. 3 ± 22. 2 ml/d） ;1 week （51.2 ± 16. 7 ml/d） ; and 2 weeks （19. 3 ± 6. 05 ml/d） （t = 5. 227,5. 549,6. 638 ; P = 0. 003, {1. （103,0. 002）. When compared with the control group,significant difference in all the posvtreatment time points （72 h later, ] week later, 2 weeks later） could be seen （t = 2. 453,2. 9t）0,2. 412;P = 1）. 029,0. 012,0. 031）. The healing time of treatment in two groupsalso had significant differenceEcontrol group 32. 8 ± 0. 75 dvsoctreotide group 25.2 ± 1.78 d] （t = 2. 512 ; P = 0. 028）. Conclusions The use of octreotide can significantly promote the resolution of chylothorax in infants and young children.
出处
《中华小儿外科杂志》
CSCD
北大核心
2012年第8期582-585,共4页
Chinese Journal of Pediatric Surgery
关键词
奥曲肽
乳糜胸
婴幼儿
Octreotide
Chylothorax
Infants and young children
