摘要
目的观察伏立康唑治疗骨科手术切口真菌感染的临床疗效及安全性。方法采用回顾性调查的方法,分析两所医院2008年1月-2011年1月使用伏立康唑治疗骨科手术切口真菌感染患者的病历资料。结果全部12例患者切口分泌物均培养出真菌,主要为假丝酵母菌属,占83.3%,包括白色假丝酵母菌5株、克柔假丝酵母菌及光滑假丝酵母菌各2株、热带假丝酵母菌1株,曲霉菌属占16.7%;伏立康唑治疗后总有效率为100.0%,有效时间为3～14d,用药清除率达100.0%;共7例患者出现不良反应,发生率为58.3%,不良反应为眼部不适3例、皮疹和消化道反应各2例,全部患者均能够耐受。结论伏立康唑是治疗骨科手术患者切口真菌感染安全有效的药物。
OBJECTIVE To observe the clinical efficacy and safety of voriconazole for the treatment of orthopedic surgical incision with fungal infections. METHODS By the means of retrospective survey, the clinical data of the patients treated with voriconazole for orthopedic surgical incision with fungal infections from Jan 2008 to Jan 2011 were analyzed. RESULTS Fungal strains were cultured from incision secretions of all the 12 patients, which were mainly the Candida （83.3%）, including five strains of C. albicans, 2 strains of C. krusei, 2 strains of C. gla- brata, and 1 strain of C. tropicalis, Aspergillus accounted for 16.7%; the total effective rate was 100.0%, the effective time was 3 to 14 days, the drug clearance rate reached to 100. 0%＇ totally 7 patients had adverse reactions, the incidence was 58.3M, the adverse reactions manifested as eye irritation （3 cases）, rash （2 cases） , and gastrointestinal reactions （2 cases ）, all patients can tolerate. CONCLUSION Voriconazole for treatment of fungal infections in orthopedic surgical incision patients is effective and safe.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第15期3357-3359,共3页
Chinese Journal of Nosocomiology
关键词
伏立康唑
真菌感染
骨科
手术切口
临床分析
Voriconazole
Fungal infections
Orthopedic
Surgical incisiom Clinical analysis
