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降钙素原在儿童细菌性血流感染诊断中的应用 被引量：13

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摘要 目的评价血清降钙素原定量检测对儿童细菌性血流感染的诊断价值。方法对该院2011年6月至2012年1月临床疑似细菌性血流感染的166例儿童患者同时进行血培养、降钙素原、超敏C反应蛋白(hs-CRP)的检测,应用SPSS17.0统计软件进行统计学分析。结果 166例同时送检的标本中,降钙素原、hs-CRP和血培养的阳性率分别为39.2%、61.4%和22.3%;以0.10作为判断截点时,降钙素原诊断的敏感性为78.3%,特异性为72.1%,阳性预测值和阴性预测值分别为44.6%、92.1%。结论定量降钙素原检测操作简单,阴性预测能力较强,对于排除血流感染具有较好的参考价值。同时,对于细菌性血流感染早期诊断有一定的敏感性,与hs-CRP相比具有较好的特异性,可连续监测患者感染状况,指导临床合理使用抗菌剂。
作者 卢敏 王中新 沈继录
机构地区 安徽医科大学第一附属医院检验科
出处 《国际检验医学杂志》 CAS 2012年第14期1776-1777,共2页 International Journal of Laboratory Medicine
关键词 血流感染 降钙素原 C反应蛋白质
分类号 R446.1 [医药卫生—诊断学]
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参考文献8

  • 1Stoll BJ, Hansen N,Fanaroff AA, et al. Changes in pathogens cau- sing early onset sepsis in very low birth weight infants[J]. N Eng J Med,2002,347(2) :240-247.
  • 2Aikawa N, Fujishima S, Endo S, et al. Multicenter prospective study of procalcitonin as an indicator of sepsis[J]. J Infect Che- mother, 2005,11(3) : 152-159.
  • 3See LL. Bloodstream infection in ehildren[J]. Pediatr Crit Care Med, 2005,6 (suppl3) : 42-44.
  • 4Ng PC, Lain HS. Diagnostic markers for neonatal sepsis[J]. Curr Opin Pediatr,2006,18(2) : 125-131.
  • 5Simon L,Gauvin F, Amre DK, et al. Serum procalcitonin and C-re- active protein levels as markers of bacterial infection ,a systematic review and meta-analysis [J]. Clln Infect Dis, 2004,39 (2):06- 217.
  • 6Kyung-Eun Kim,Jin-Yeong MD, Han MD. Evaluation of the clini- cal performance of an automated procalcitonin assay for the quan- titative detection of bloodstream infection[J]. Korean J Lab Med 2010,30(2):153-159.
  • 7Charles PE, Ladoire S, Aho S, et al. Serum proealcitonin elevation in critically ill patients at the onset of baeteremia caused by either gram negative or gram positive baeteria[J]. BMC Infect Dis,2008, 8:38.
  • 8张有江,王欢,罗燕萍,刘朝军,陈荣,赵强,刘冰,王晓宁.定量降钙素原测定在血流感染诊断中的应用[J].军医进修学院学报,2010,31(12):1219-1221. 被引量：32

二级参考文献11

  • 1Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States : analysis of incidence, outcome, and associated costs of care [ J ] . Crit Care Med, 2001, 29 ( 7 ) : 1303-1310.
  • 2Dombrovskiy VY, Martin AA, Sunderram J, et al. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States : a trend analysis from 1993 to 2003 [ J ]. Crit Care Med, 2007, 35 ( 5 ) : 1244-1250.
  • 3Aikawa N, Fujishima S, Endo S, et al. Muhicenter prospective study of procalcitonin as an indicator of sepsis [ J ] . J Infect Chemother, 2005, 11 (3) : 152-159.
  • 4Reith HB, Mittelkotter U, Wagner R, et al. Procaleitonin (PCT) in patients with abdominal sepsis [ J ] . Intensive Care Med, 2000, 26 Suppl 2 : S165-S169.
  • 5Schuetz P, Mueller B, Trampuz A. Serum procalcitonin for discrimination of blood contamination from bloodstream infection due to coagulase-negative staphylococci [ J ] . Infection, 2007, 35 ( 5 ): 352-355.
  • 6Assicot M, Gendrel D, Carsin H, et al. High serum procalcitonin eoncentralions in patients with sepsis and infection [ J 1 . Lancet, 1993, 341 ( 8844 ) : 515-518.
  • 7Ferri e re F. Procaicitonin ,a new marker for bacterial infections [ J ].Ann Biol Clin (Paris), 2000, 58 ( 1 ) : 49-59.
  • 8Meisner M, Tschaikowsky K, Schmidt J, et al. Procalcitonin (PCT)-Indications for a new diagnostic parameter of severe bacterial infection and sepsis in transplantation, immunosupprcssion and cardiac assist devices [ J ] . Cardiovasc Eng, 1996, 1 : 67-76.
  • 9Sponholz C, Sakr Y, Reinhart K, et al. Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery : a systematic review of the literature [ J ] . Crit Care, 2006, 10 ( 5 ): R145.
  • 10Uzzan B, Cohen R, Nicolas P, et al. Procalcitonln as a diagnostic test for sepsis in critically ill adults and after surgery or trauma : a systematic review and meta-analysis [ J ] . Crit Care Med, 2006, 34 ( 7 ) : 1996-2003.

共引文献31

同被引文献107

  • 1金汉珍,黄德珉,官希吉.实用新生儿[M].第3版,北京:人民卫生出版社,2003.971.
  • 2素亮亮,武雅俐,周东芳,等.降钙索原(PCT)检测在儿童感染性疾病的床应用[J].中国妇幼保健,2011,22(8):872-876.
  • 3Beck KL,Snider R,Nylen ES.Procalcitonin assay in systemic inflammation,infection,and sepsis:clinical utility and limitations[J].Crit Care Med,2008(3):941-952.
  • 4Ferriere F.Procalcitonin,a new marker for bacteria infections[J].Ann Biol Clin,2000(1):49-59.
  • 5Haeuptle J,Zaborsky R,Fiumefreddo R,et al.Prognostic value of procalcitonin in legionella pneumonia[J].Eur J Clin Microbiol Infect Dis,2009(1):55-60.
  • 6Ramathaler F,Ketlner M,Mall G,et al.The use of rapaid diagnositic test of procalcitonin serum level for the postmortem diagnosis of sepsis[J].Forensic Sci Int,2008(2-3),139-145.
  • 7Karlsson S, Hcikkinen M, Pettia V, et al. Predictive value of pro- caleitonin decrease in patients with severe sepsis: a prospective observational study [ J ]. Critical Care,2010,14 (6) : R205.
  • 8Kim KE, Han JY. Evaluation of the clinical performance of an au- tomated procalcitonin assay for the quantitative detection of blood- stream infection[J]. Korean J Lab Med,2010,30(2) :153-159.
  • 9Fagan RP, Edwards JR, Park B J, et al. Incidence trends in patho- gen-specific central line-associated bloodstream infections in US intensive care units, 1990-2010[ J]. Infect Control Hosp Epidemi- ol,2013,34(9) :893-899.
  • 10MeisnerM.降钙素原-生化与临床诊断[M].Bremen:UNI-MED,2010:9.

引证文献13

二级引证文献72

国际检验医学杂志
2012年 第14期

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