摘要
目的评价香菇多糖联合吉西他滨和顺铂(GP方案)治疗晚期非小细胞肺癌(NSCLC)的近期疗效及对患者生活质量的影响。方法将51例ⅢB和Ⅳ期NSCLC患者随机分为治疗组25例和对照组26例,均给予吉西他滨1 000 mg·(m2)-1,第1,8天静脉滴注;顺铂25 mg·(m2)-1,第2～4天静脉滴注。21 d为1个周期,两个周期后评价疗效。治疗组同时给予香菇多糖2 mg+5%葡萄糖注射液或0.9%氯化钠注射液250 mL,第1,4天静脉滴注。两组化疗前均给予5-羟色胺受体拮抗药预防性止吐,并常规给予水化利尿处理。结果两组QLQ-C30生活质量评分均较治疗前升高,治疗组整体生活质量评分显著高于对照组,乏力较对照组显著改善(P<0.05);两组QLQ-LC-13肺癌相关症状(咳嗽、呼吸困难、胸痛)评分较治疗前均下降;治疗组细胞免疫功能较治疗前无变化,对照组免疫功能下降,两组治疗后比较差异有统计学意义(P<0.05);对照组白细胞减少多于治疗组。结论香菇多糖联合GP方案化疗治疗晚期非小细胞肺癌可有效控制NSCLC进展,减轻化疗不良反应,预防患者细胞免疫功能损伤,明显改善患者的生活质量。
Objective To evaluate the short-term efficacy and influence of lentinan combined with gemcitabine and cisplatin（GP regimen） on life quality of patients with advanced non-small cell lung cancer（NSCLC）.Methods Fifty-one cases histologically confirmed Ⅲb and Ⅳ stage of NSCLC were enrolled and allocated to treatment group（n=25） and control group（n=26） randomly.The treatment group received lentinan combined with GP regimen： Lentinan 2 mg intravenously guttae（ivgtt） on days 1 and 4,gemcitabine 1 000 mg·（m^2）^-1 ivgtt on days 1 and 8 combined with cisplatin 25 mg·（m^2）^-1 ivgtt on days 2 to 4 in a cycle of 21 days;the control group were treated with simple GP regimen： gemcitabine 1 000 mg·（m^2）^-1 ivgtt on days 1 and 8,cisplatin 25 mg·（m2）-1 ivgtt on days 2 to 4 in a cycle of 21 days.The efficacy and toxicities were evaluated after two cycles.Results The scores of QLQ-C30 in the treatment group and the control group were both improved after the treatment,but the global score of QLQ-C30 was significantly higher in the treatment group than in the control group（P〈0.05）.The incidence of fatigue was significantly decreased in the treatment group as compared with the control group（P〈0.05）.The scores of QLQ-LC-13（cough,dyspnea and chest pain） in the treatment group and control group were both decreased after the treatment,and the difference was not statistically significant（P〈0.05）.Cell immune function didn＇t change before and after the chemotherapy in the treatment group,but declined in the control group（P〈0.05）.The incidence of leucopenia was significantly higher in the control group than in the treatment group（P〈0.05）.The differences of remission rate and the incidence of gastrointestinal disorder were not statistically significant（P〈0.05）.Conclusion Lentinan combined with GP regimen can effectively keep disease progression under control,comparing with control group,and alleviate adverse reaction induced by chemotherapy and significantly improve the quality of life in patients with advanced NSCLC.
出处
《医药导报》
CAS
北大核心
2012年第8期1029-1032,共4页
Herald of Medicine
关键词
香菇多糖
吉面他滨
顺铂
癌
非小细胞肺
生活质量
不良反应
Lentinan
Gemcitabine
Cisplatin
Non-small cell lung cancer
Quality of life
Adverse reaction
