摘要
目的:探讨抗环瓜氨酸肽抗体(抗-CCP)、(AKA)及类风湿因子(RF)3个指标单项及联合检测对类风湿关节炎(RA)的诊断价值。方法:抗-CCP采用电化学发光法定量检测,RF采用速率散射免疫比浊法检测法,AKA采用免疫荧光法。结果:RA组单项指标中敏感性RF>抗CCP>AKA,特异性抗CCP>AKA>RF,联合检测指标抗CCP+AKA、抗CCP+RF、AKA+RF阳性时特异性分别提高到99.2%、96.9%、94.7%,阳性预测值为98.3%、94.6%、92.3%,抗CCP+AKA+RF三项指标均阳性时,特异性、阴性预测值和阳性预测值均100%。结论:抗CCP、AKA和RF联合检测比单项指标具有更高的特异性和阴阳性预测值,可进一步提高对RA的早期诊断率,尤其是对临床症状不典型的早期RA患者意义更大。
Objective：To study the values of anti- CCP, AKA and RF in diagnosis of Rheumatoid Arthritis. And the values of method of united with three indexes were compared with. Methods： Anti - CCP, AKA and RF measured with different means, such as ECLIA,the rate scatting immunity method, and immunity fluorescence technique. Results：The value in sensitivity of using the single index,the best was RF. And in specificity the best was anti - CCP. When united with three indexes, the sensitivity and specificity were raised obviously. Conclusion：The method united with anti - CCP, AKA and RF in diagnosis of Rheumatoid Arthritis was very effective in early patients.
关键词
抗环瓜氨酸肽抗体
抗角蛋白抗体
类风湿因子
类风湿关节
炎联合检测
Rheumatoid Arthritis（RA）
An-ti - cyclic citrullinuria peptide antibody （ anti- CCP ）
Anti - RA keratin antibody
