摘要
目的:探讨化瘀通阳灌肠方改善高凝状态对溃疡性结肠炎肠黏膜修复的影响。方法:采用随机、对照、单盲将60例溃疡性结肠炎患者分为治疗组(化瘀通阳方+强的松龙)灌肠+柳氮磺吡啶(SASP)口服;对照组(0.9%氯化钠溶液+强的松龙)灌肠+SASP口服,疗程均为1个月。检测治疗前后外周血血小板计数(PLT)、血小板平均体积(MPV)、血小板最大聚集率(PAGMax)、纤维蛋白原(FIB)、D-二聚体(D-D)、C-反应蛋白(CRP)、血清白蛋白(ALB)。结果:治疗组治疗后PLT、PAGMax及D-D均较治疗前下降(P<0.05,P<0.01);MPV治疗后较治疗前升高,差异有统计学意义(P<0.01)。治疗组治疗后较治疗前FIB下降,但差异无统计学意义。治疗组CRP与PAGMax和D-D均显著下降,但无明显相关性。治疗后治疗组白蛋白均数高于对照组(P<0.05)。治疗组中医证候积分的改善明显优于对照组(P<0.01)。结论:化瘀通阳灌肠方与对照组相比可改善溃疡性结肠炎肠屏障高凝状态,但其血液高凝状态与活动性不存在明显相关性。
Objective：The study discusses the influence on repair of intestinal barrier by improving the hypercoagulation of ulcerative colitis by Huayu Tongyang Enema Recipe.Methods：Study utilized randomized,single-blind,contrastived research method.60 cases were divided into treatment group and control group respectively.The treatment group received the therapy of clysis with the Huayu Tongyang Enema Recipe 150mL and prednisolone 125mg,along with SASP per os,while the control group received clysis of normal saline（NS） 150mL and prednisolone 125mg,with SASP per os.The course of treatment lasted for a month.Results：Comparing the two groups before and after treatment on PLT,MPV,PAGMax,FIB and D-D,we found that PLT,PAGMax and D-D down regulated after treatment of treatment group（P〈0.05,P〈0.01）;while regulated MPV increased after treatment,with the two sets of data statistically significant.Moreover,the change of control group was not significant.Regulated FIB of treatment group decreased after treatment but wasn＇t significant.The up-regulation of CRP indicated the activity of UC,while there was no significant difference of CRP＇s level between the two groups.The activity marker CRP combined with the blood coagulation index PAGMax and D-D,markedly down-regulated after the treatment group.However,there was no significant correlation of CRP with PAGMax,or CRP with D-D.ALB mean of treatment group increased after treatment was significant difference（P〈0.05）.The TCM syndrome scoring was higher than those of the control group（P〈0.01）.Conclusion：The adoption of the Huayu Tongyang Enema Recipe intervened in hypercoagulation of intestinal barrier,which markedly preceded control group.However,this research does not prove that inflammation activity of UC has a direct association with blood hypercoagulability.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2012年第8期2155-2157,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
天津市卫生局中医中西医结合基金项目(No.07070)~~
关键词
化瘀通阳灌肠方
溃疡性结肠炎
高凝状态
Huayu Tongyang Enema Recipe
Ulcerative colitis
Hypercoagulation
