摘要
目的:考察夏天无饮片超微粉碎前后对小鼠口服生物利用度的影响。方法:样品为夏天无超微饮片和普通饮片各1 g.mL-1,以10 mL.kg-1ig给药,1次/天,共7 d,研究醋酸所致小鼠扭体反应的镇痛作用及血液中所含生物碱量的相关性。结果:夏天无超微粉碎后,对醋酸所致小鼠扭体反应的抑制作用强于普通饮片(P<0.05),超微粉组镇痛作用强于普通饮片约4%,同时血液中生物碱的含量高于普通饮片约5%。结论:夏天无超微粉碎后提高了生物利用度。
Objective： To study the correlation of plasma concentration before and after ultrafine grinding and Corydalis Decumbentis Rhizoma bioavailability by oral administration in mice. Method： Acetic acid induced writhing response was used to observe analgesic effect in mice and the blood contained in the amount of alkaloids. Result： By ultrafine grinding of Corydalis Decumbentis Rhizoma, stronger inhibitory effect on acetic acid induced writhing response was fund compared with the ordinary pieces, alkaloid content in the bloOd was higher than ordinary pieces. Conclusion ： Ultrafine grinding can improve the bioavailability of Corydalis Decumbentis Rhizoma.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第17期231-234,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
中医药行业科研专项项目(200807054)
关键词
夏天无普通饮片
夏天无超微饮片
生物碱
镇痛
ordinary pieces of Corydalis Decumbentis Rhizoma
ultrafine powder of Corydalis Decumbentis Rhizoma
alkaloid
analgesic
