摘要
目的:观察半夏泻心汤预防伊力替康导致的迟发性腹泻的疗效。方法:55例患者分为两组:中药组26例,在化疗前1天起口服半夏泻心汤连续5天;对照组29例,两组均接受含伊力替康的化疗方案各60疗程,对两组患者腹泻、恶心呕吐发生情况及血液学毒性进行观察。结果:中药组迟发性腹泻发生率为11.7%,对照组为26.7%,出现统计学差异(P<0.05);Ⅲ～Ⅳ度迟发性腹泻中药组未见发生,对照组出现3例,但对比未见统计学差异(P>0.05);治疗期间两组恶心呕吐均以Ⅰ至Ⅱ度为主,中药组恶心呕吐发生率为65.0%,对照组为88.3%,两组间出现统计学差异(P<0.05);中药组白细胞下降Ⅲ～Ⅳ度为30.0%,血小板达Ⅲ～Ⅳ度下降为16.7%;对照组白细胞下降达Ⅲ～Ⅳ度26.7%,血小板达Ⅲ～Ⅳ度下降为18.3%,组间均未见统计学差异(P>0.05)。结论:半夏泻心汤能预防伊力替康导致的迟发性腹泻,减少化疗后恶心呕吐发生。
Objective： To observe the preventive efficacy on irinotecan - induced delayed diarrhea by Banxia Xiexin Decoction. Methods： Total of 55 patients with advanced cancer were assigned into herb group（ n = 26）and control group （ n = 29）. Chemotherapy included irinotecan was given for 60 cycles in each group and patients in the herb group were administrated with Banxia Xiexin Decoction once a day from lday before chemotherapy to 5 days after chemotherapy. The side effects such as myelosuppression, diarrhea, nausea and vomiting were evaluated. Results： The delayed diarrhea inci- dences induced by irinotecan in herb group and control group were 11.7 % and 26.7 %, respectively （ P 〈 0.05 ）. There were no obvious changes of grade 11I - Iv＇diarrhea in two groups（ P 〉0.05）. The incidences of nausea and vomiting in herb group and control group were 65.0% and 88.3 %, respectively（ P 〈 0.05）, and grade I - 11 nausea and vomiting were major reaction. Myelosuppression such as grade llI- IV leucopenia and thrombocytopenia in treatment group were 30.0% and 16.7% ,while that were 26.7% and 18.3% in control group（ P 〉 0. 05）. Conclusion： Banxia Xiexin De- coction could prevent irinotecan - induced delayed diarrhea and decrease occurrences of chemotherapy - induced nausea and vomiting.
出处
《中华中医药学刊》
CAS
2012年第9期2020-2022,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中医药管理局资助项目(2010ZB006)
关键词
半夏泻心汤
伊力替康
迟发性腹泻
恶心呕吐
Banxia Xiexin Decoction
irinotecan
delayed diarrhea
nausea and vomiting
