摘要
目的探讨更昔洛韦治疗眼部带状疱疹的临床效果。方法将眼部带状疱疹患者52例分为两组,治疗组28例用更昔洛韦针剂0.25 g/d,静脉滴注,对照组24例用阿昔洛韦0.5 g/d,静脉滴注,均连续使用10天,比较两组临床疗效,主要观察项目及不良反应。结果治疗组有效率(92.9%)明显高于对照组(58.3%),带状疱疹的止痛时间、止疱时间及结痂时间均明显短于对照组,差异均有统计学意义(P<0.05)。两组均无任何眼部后遗症,不良反应均轻微。结论更昔洛韦治疗眼部带状疱疹具有疗效好、见效快、症状改善显著,值得临床推广应用。
Objective To investigate the clinical effect of ganciclovir on treatment of herpes zoster ophthaimicus. Methods Fifty-two cases with herpes zoster ophthalmicus were randomly divided into two groups. In the treatment group （ n = 28） were treated with intravenous drip of 0.25 g/day of ganciclovir while in the control group （ n = 24） were treated with intravenous drip of 0.5 g/day of acyclovir. The treatments were continuously performed for 10 days. Curative effect and adverse drug reaction were compared between two groups. Results time of analgesia, time to stop vesiculation＂ and scab formation time were all significantly shorter in the treatment group than that in the control group （ P 〈 0.01 ）. The efficient rate of treatment group was obviously higher than that of control group （92.9% vs. 58.3% ,P 〈 0.01 ）. There were no any ocular sequelae neither in treatment or control groups. However,a mild adverse drug reaction was observed in both groups. Conclusions Ganciclovir has a good and quick curative effect, and can improve symptoms significantly in treatment of herpes zoster ophthalmicus. Therefore,it＇ s worth to be popularized in clinical application.
出处
《实用医院临床杂志》
2012年第5期182-183,共2页
Practical Journal of Clinical Medicine
