摘要
目的:观察疏血通联合阿托伐他汀治疗短暂性脑缺血发作(TIA)的作用及初步探讨其作用机制。方法:回顾分析2009年8月～2010年12月我院收治的46例TIA的患者。采用疏血通+阿托伐他汀进行治疗。收集治疗前后的凝血功能、血脂、空腹血糖、颈动脉彩超等临床资料。出院后继续服用阿托伐他汀至6个月。所有患者均随访6～12个月。结果:疏血通联合阿托伐他汀治疗TIA,总有效率达91.30%(42/46),随访发现治愈或有效42例中复发TIA或发生脑卒中5例,发生率为11.90%。治疗6个月后,患者低密度脂蛋白胆固醇(LDL-C)和甘油三酯(TG)水平较治疗前明显下降,与治疗前比较差异有统计学意义(P<0.05)。治疗6个月后,治疗后患者颈动脉内膜厚度(IMT)明显变薄,斑块面积明显变小,与治疗前比较差异有统计学意义(P<0.05)。结论:疏血通联合阿托伐他汀治疗TIA疗效好,且可降低TIA的复发和脑卒中发生率,可能与降低LDL-C和TG水平、缩小IMT和斑块面积有关。
To observe the therapeutic effect of Shuxuetong combined with atorvastatin for treating transi- ent ischemic attack （TIA）. METHODS： We retrospect 46 cases of TIA patients from August 2009 to December 2010 in our hospital treated with Shuxuetong combined with atorvastatin. The clinical data such as coagulation function, blood lip- id, fasting blood glucose andthe carotid color Doppler ultrasonic examination before and after treatment were collected. All patients continued to take atorvastatin for 6 months and were followed up for 6 to 12 months. RESULTS ： The total effec- tiveness of using Sbuxuetong combined with atorvastatin for TIA in 46 cases was 91.30%. Five patients were found to suffer from recurrent TIA or the occurrence of stroke in the cured or effective 42 cases during follow - up, the incidence of which was 11.90%. Six months after treatment, low - density lipoprotein - cholesterol （ LDL - C） and triglycerides （TG） were obviously lower than those before treatment （P 〈 0. 05）, and the carotid intimal thickness （IMT） and the plaque area were decreased as compared with those before treatment （P 〈 0. 05 ）. CONCLUSION ： Treatment with Shuxuetong ＋ atorvasta- tin for TIA has good therapeutic effect and reduces the recurrence of TIA and stroke incidence, which may be related to the reduction of LDL - C and TG levels, IMT and the plaques area.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2012年第8期1513-1515,共3页
Chinese Journal of Pathophysiology
