摘要
目的观察冠心病(CHD)患者血浆Apelin-12水平的变化,探讨其与冠状动脉狭窄严重程度的关系。方法依据冠脉造影(CAG)检查结果确诊为冠心病的患者59例,冠脉造影结果排除冠心病患者为正常对照组35例。用放免法测定血浆Apelin-12和hs-CRP水平,分析其与冠脉病变Gensini评分的相关性。结果与对照组相比,冠心病患者血浆Apelin-12水平降低,差异有统计学意义(P<0.01),血浆Apelin-12水平和冠脉病变Gensini评分间存在显著的负相关性(r=-0.342,P<0.05)。结论血清Apelin-12水平和冠脉病变狭窄程度有关,提示Apelin可能参与冠状动脉粥样硬化病理生理过程。
Objective To explore the plasma Apelin-12 level changes of coronary heart disease （ CHD ） patients ,analyze the relation- ship between the level changes and coronary artery stenosis severity in coronary heart disease. Methods 59 patients who were diagnosed as coronary heart disease and 35 patients were divided into the normal control group according to the coronary angiography findings. Radioimmunoassay was used to measure the plasma Apelin-12 and hs-CRP levels, analysis it＇s relationship between Gensini score. Results Compared with control group, the plasma Apelin-12 level in patients with coronary heart disease decreased, the difference was statistically difference （P 〈0.01 ） ,plasma Apelin-12 levels and coronary lesion score of Gensini has significant negative correlation （r = -0.342 P 〈 0. 05）. Conclusion The level of plasma Apelin-12 associated with the severity of cornoary atherosclerosis , suggesting that Apelin may be involved in the pathophysiology of coronary atherosclerosis.
出处
《安徽医药》
CAS
2012年第9期1295-1296,共2页
Anhui Medical and Pharmaceutical Journal
基金
合肥市科研基金项目(No合科(2011)25号)
