摘要
利用静电纺丝技术制备了质量分数为10%的黄连素/聚乙烯醇(PVA)和黄连素/聚乙烯吡咯烷酮(PVP)超细纤维,通过红外光谱及扫描电镜照片进行了结构和性能的表征,紫外-可见光分光度计测试了载药超细纤维在人工肠液和人工胃液的体外释药行为。PVP载药纤维膜的累计释药率明显高于PVA载药纤维膜。PVA载药纤维具有较好的缓释效果,有一定的靶向药位;PVP超细纤维膜能够将难溶药物黄连素速溶于体液中,达到提高难溶药物生物利用度的目的。
The micro-fibers of berberine/poly （vinyl alcohol） （PVA） and berberine/poly （vinyl pyrrolidone） （PVP） were prepared by electrospun technique, whose weight percentage was 10%, respectively. Structures and morphologies of loaded medicine in fibers were characterized by fourier transformation infrared spectroscopy and scanning electron microscopy for different carrier systems. Using ultraviolet-visible spectrometer, the sustained release of medicine was investigated under the conditions of the simu- lated intestinal fluid and gastric juice. The berberine/PVP fibers showed higher cumulative drug release percentage than berberine/ PVA fibers for the same content. The loaded medicine in the PVA fibers indicated effective sustained--release and targeted drug delivery. The fibrous berbebrine/PVP was able to dissolve quickly in the artificial body fluid and exhibited potential to improve the bioavailability of dissolution and absorbance of poorly water-soluble drugs.
出处
《化工新型材料》
CAS
CSCD
北大核心
2012年第9期31-33,共3页
New Chemical Materials
基金
吉林医药学院科研基金资助项目(200908)
关键词
静电纺丝
载药纤维
缓释
生物利用度
electrospinning,loaded fiber, sustained-release, bioavailability
