摘要
目的了解血清可溶性髓系细胞触发受体-1(sTREM-1)对重症肺炎病情及预后的评价意义。方法 46例重症肺炎患者入院后第1、3、7天用ELISA检测血清sTREM-1水平,并进行APACHEⅡ评分及SOFA评分,分析sTREM-1与APACHEⅡ及SOFA评分的相关性。结果生存30例,死亡16例。死亡组的sTREM-1水平、APACHEⅡ和SOFA评分明显高于生存组(P<0.01)。第7天sTREM-1水平与APACHEⅡ评分(r=0.513,P<0.01)和SOFA评分(r=0.611,P<0.01)呈正相关。根据ROC曲线分析,入院后第1、3、7天sTREM-1对重症肺炎存活或死亡进行预测的曲线下面积分别为0.648(95%CI0.475～0.821)、0.750(95%CI0.607～0.893)和0.842(95%CI0.715～0.969)。结论检测血清sTREM-1水平有助于判断重症肺炎病情及预后。
Objective To study the significance of soluble triggering receptor expressed on myeloid cells-1 （sTREM-1） in evaluating the condition and prognosis of patients with severe pneumonia. Methods Serum level of sTREM-1 was determined by ELISA in 46 cases of severe pneumonia on days 1, 3 and 7 after admission, and APACHE Ⅱ and SOFA scores were also evaluated. The relationship between sTREM-1 level and APACHE Ⅱ and SOFA scores was analyzed. Results There were 30 survivals and 16 deaths. The sTREM-1 level and APACHE Ⅱ and SOFA scores were significantly higher in death group than those in survival group （P〈0.01）. The sTREM-1 level was positively correlated with APACHE Ⅱ （r=0.513, P〈0.01） and SOFA scores （r=0.611, P〈0.01） on day 7. The areas under the ROC curve of sTREM-1 level for predicting survival or death in patients with severe pneumonia were 0.648 （95% CI, 0.475～0.821）, 0.750 （95% CI, 0.607～0.893） and 0.842 （95% CI, 0.715～0.969） on days 1, 3, and 7, respectively. Conclusion Serum sTREM-1 level is helpful for evaluating the condition and prognosis of patients with severe pneumonia.
出处
《广东医学院学报》
2012年第4期383-386,共4页
Journal of Guangdong Medical College
