摘要
目的探讨静脉注射丙种球蛋白对肺炎合并心力衰竭患儿B型利钠肽(BNP)及心功能的影响。方法对照组患儿28例予以常规综合治疗;治疗组患儿29例在对照组治疗基础上加用丙种球蛋白40 mg/(kg.d)静脉滴注,连续应用3 d。测定两组患儿入院后24 h内及治疗1周后血BNP水平、左室舒张末期内径(LVEDD)、左室舒张末期内径指数(LVEDDI)、左室射血分数(LVEF)、左室短轴缩短率(LVFS)等。结果两组患儿治疗前后BNP、LVEDDI、LVEF、LVFS比较,差异有统计学意义;治疗组治疗后与对照组BNP(P<0.01)、LVEDDI(P<0.01)、LVEF(P<0.05)、LVFS(P<0.05)比较,差异有统计学意义。治疗前BNP与LVEF呈负相关(r=-0.77,P<0.01,n=57),治疗后BNP与LVEF无关(r=-0.326,P=0.26,n=57)。结论在常规治疗小儿重症肺炎合并心力衰竭的基础上加用丙种球蛋白可更显著改善心功能各项指标,抑制BNP释放。
Objective To investigate the influence of intravenous immunoglobulin on the BNP concentration and the cardiac function in children with pneumonia complicated with heart failure.Methods 28 cases in the control group were given the routine treatment,while 29 cases in the treatment group were added with immunoglobulin 40 mg/（kg·d） by intravenous dripping,for continuous 3 d.The blood BNP levels,left ventricular end diastolic diameter（LVEDD）,left ventricular end diastolic diameter index（LVEDDI）,left ventricular ejection fraction（LVEF）,left ventricular fractional shortening（LVFS）in 24 h after admission and after 1-week treatment were determined in the two groups.Results Before and after treatment,BNP,LVEDDI,LVEF and LVFS had statistical differences between the control group and the treatment group.After treatment,BNP（P〈0.01）,LVEDDI（P〈0.01）,LVEF（P〈0.05） and LVFS（P〈0.05） showed statistical differences between the two groups.Before treatment,BNP and LVEF were negatively correlated（r=-0.77,P〈0.01,n=57）.But after treatment,BNP with LVEF had no correlation（r=-0.326,P=0.26,n=57）.Conclusion Based on the routine therapy,adding immunoglobulin can significantly improve the various indexes of the heart function and inhibit the BNP release in children with severe pneumonia complicated with heart failure.
出处
《现代医药卫生》
2012年第18期2743-2744,共2页
Journal of Modern Medicine & Health
关键词
肺炎/并发症
心力衰竭/并发症
利钠肽
脑
心脏/病理生理学
丙种球蛋白类
注射
静脉内
儿童
Pneumonia/complications
Heart failure/complications
Natriuretic peptide,brain
Heart physiopathology
gamma-globulins
Injections,intravenous
Child
