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右美托咪啶的镇痛机制及临床应用 被引量:27

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摘要 右美托咪啶(dexmedetomidine,DXM)是一种继可乐定之后的高效、高选择性的α2肾上腺素受体激动剂。具有剂量依赖性的镇静、镇痛、抗焦虑、交感神经抑制、对呼吸影响小、脑保护等作用。右美托咪啶作为镇静、镇痛药物已广泛用于临床。本文就右美托咪啶的镇痛机制及其在疼痛控制方面的临床应用进行介绍。
作者 张惠 王国年
出处 《西部医学》 2012年第9期1828-1829,1833,共3页 Medical Journal of West China
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  • 1Gil DW, Cheevers CV, Kedzie KM, Manlapaz CA, Rao S, Tang E, Donello ]E: Alpha-l-adrenergic receptor agonist activi- ty of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia[J]. Anesthesiology, 2009, 110(2) :401-407.
  • 2Massad IM, Mohsen WA, Basha AS, A1-Zaben KR, AI-Musta- fa MM, Alghanem SM: A balanced anesthesia with dexmedeto- midine decreases postoperative nausea and vomiting after laparo- seopic surgery[J]. Saudi Med J, 2009, 30(12) :1537-1541.
  • 3A1-Zaben KR, Qudaisat IY, AI-Ghanem SM, Massad IM, AI- Mustafa MM, AI-Oweidi AS, Abu-Halaweh SA, Abu-Ali HM, Saleem MMz Intraoperative administration of dexmedetomidine reduces the analgesic requirements for children under-going hy- pospadius surgery[J]. Eur J Anaesthesiol, 2010, 27 (3) : 247- 252.
  • 4Yuen VM, Hui TW, Irwin MG, Yuen MK: A comparison of intranasal dexmedetomidine and oral midazolam for pre-medica- tion in pediatric anesthesia: a double-blinded randomized con- trolled trial[J]. Anesth Analg, 2008, 106(6):1715-1721.
  • 5Lin TF, Yeh YC, Lin FS, Wang YP, Lin CJ, Sun WZ, Fan SZ, Effect of combining dexmedetomidine and morphine for in- travenous patient-controlled analgesia[J]. Br J Anaesth, 2009, 102(1) : 117-122.
  • 6Brummett CM, Trivedi KA, Dubovoy AV, Berland DW:Dexmedetomidine as a novel therapeutic for postoperative pain in a patient treated with buprenorphine[J]. J Opioid Manag, 2009,5(3):175-179.
  • 7Sanders RD, Xu J, Shu Y, Januszewski A, Halder S, Fidalgo A, Sun P, Hossain M, Ma D, Maze M: Dexmedetomidine at- tenuates isoflurane-induced neurocognitive impairment in neo- natalrats[J]. Anesthesiology, 2009, 110(5) :1077-1085.
  • 8Patel A, Davidson M, Tran MC, Quraishi H, Schoenberg C, Sant M, Lin A, Sun X, Dexmedetomidine infusion for analgesia and prevention of emergence agitation in children with obstruc- tive sleep apnea syndrome undergoing tonsillectomy and ade- noidectomy[J]. Anesth Analg, 2010, 111(4) :1004-1010.
  • 9Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, Whitten P, Margolis BD, Byrne DW, Ely EW, Rocha MG; SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group: Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial[J]. JAMA, 2009, 301(5),489-499.
  • 10Shehabi Y, Grant P, Wolfenden H, Hammond N, Bass F, Campbell M, Chen J : Prevalence of delirium with dexmedetomi- dine compared with morphine based therapy after cardiac sur- gery: a randomized controlled trial (DEXmedetomidine COm- pared to Morphine-DEXCOM Study) [J]. Anesthesiology, 2009,111(5) : 1075-1084.

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