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宫颈癌患者淋巴结HPV-DNA及血清SCCA检测的临床意义 被引量：1

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摘要 目的探讨宫颈癌患者淋巴结HPV-DNA及术前血清鳞状细胞癌抗原(SCCA)水平与淋巴结转移之间的关系。方法采用实时荧光定量PCR法检测50例宫颈癌患者的宫颈原发部位及盆腔淋巴结HPV-DNA,同时检测其术前血清SCCA水平。结果宫颈癌患者原发部位HPV-DNA检出率为92.0%(46/50),盆腔淋巴结中HPV-DNA检出率为28.0%(14/50),11例组织学阳性淋巴结HPV-DNA检出率为100%(11/11),39例组织学阴性淋巴结HPV-DNA检出率为7.7%(3/39);60%宫颈癌患者血SCCA升高(30/50);淋巴结转移与淋巴结HPV-DNA阳性和术前SCCA水平相关(P均<0.01),淋巴结HPV-DNA阳性与术前SCCA水平相关(P<0.05)。结论 HPV-DNA在阳性淋巴结中高度表达,与淋巴结转移密切相关,术前SCCA水平与淋巴结转移相关,术前SCCA水平和淋巴结HPV-DNA阳性可以作为淋巴结转移的预测因子。
作者 王洪珍 刘大标 殷朝晖 陈英
机构地区 镇江市第四人民医院
出处 《山东医药》 CAS 2012年第33期55-57,共3页 Shandong Medical Journal
关键词 宫颈肿瘤 乳头状瘤病毒 人 淋巴结转移 鳞状上皮癌抗原
分类号 R737.33 [医药卫生—肿瘤]
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参考文献11

  • 1Kamangar F, Dores GM, Anderson WF, et al. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world[ J]. J Clion Oncol, 2006,24 (14) :2137-2150.
  • 2Ylitalo N, Josefsson A, Melhye M, et al. A prospective study show- ing long-term infection with human papillomavirus 16 before the de- velopment of cervical carcinoma in situ [ J ]. Cancer Res, 2000,60 (21) :6027-6032.
  • 3S16ma J, Drazd6kov6 M, Fischerov6 D, et al. Detection of HPV DNA in lymph nodes in early stages cervical cancers[ J]. Ceska Gy- nekol, 2008,73(4) :217-221.
  • 4Shibata D, Cosgrove M, Arnheim N, et al. Detection of human pap- illomavirus DNA in fine-needle &spirations of metastatic squamous- cell carcinoma of the uterine cervix using the polymerase China reac- tion[J]. Diagn Cytopathol, 1989,5( 1 ) :40-43.
  • 5Siriaunkgul S, Suwiwat S, Settakom S, et al. HPV genotyping in cervical cancer in Northern Thailand : adapting the linear array HPV assay for use on paiaffin-embedded tissue [ J ]. Gynecol Oncol, 2008,108 (3) :555-560.
  • 6孙颖,刘国炳,余艳红.盆腔淋巴结HPV-DNA检出率与早期宫颈癌临床转移的关系[J].南方医科大学学报,2008,28(5):796-798. 被引量：10
  • 7Chan PK, Yu MM, Cheng TH, et al. Detection and quantitation of human papillomavirus DNA in primary tumour and lymph nodes of patients with early stage cervical carcinoma [ J ]. J Clin Virol, 2005, 33(3) :201-205.
  • 8熊樱,梁立治,郑敏,魏梅,沈扬.鳞状细胞癌抗原与子宫颈鳞状细胞癌的临床病理特征及预后的关系[J].中华妇产科杂志,2007,42(1):29-33. 被引量：36
  • 9Kotowicz B, Fuksiewicz M, Kowalska M, et al. The value of tumor marker and cytokine analysis for the assessment of regional lymph node status in cervical cancer patients [ J] . Int J Gynecol Cancer, 2008,18 ( 6 ) : 1279 -1284.
  • 10Takeshima N, Hirai Y, Katase K, et al. The value of squamouse cell carcinoma antigen as a predictor of nodal metastasis in cervical cancer[ J]. Gynecol Oncol, 1998,68 ( 3 ) :263-266.

二级参考文献28

  • 1荆结线,邵淑丽,田保国,韩存芝,赵先文,杜丽丽,张中书.宫颈癌SCCAg检测及其临床意义[J].中国肿瘤临床,2005,32(21):1242-1244. 被引量：13
  • 2Huang CY,Chen YL,Chu TC,et al. Prognostic factors in women with early stage small cell carcinoma of the uterine cervix[J]. Oncol Res,2009,18(5-6) : 279-286.
  • 3Albores-Saavedra J, Gersell D, Gilks CB, et al. Terminology of endocrine tumors of the uterine cervix: results of a workshop sponsored hy the College of American Pathologists and the Na- tional Cancer Institute[J]. Arch Pathol Lab Med, 1997,121 (1) : 34-39.
  • 4Chan JK,Loizzi V,Burger RA,et al. Prognostic factors in neuro- endocrine small cell cervical carcinoma: a multivariate analysis [J]. Cancer, 2003,97(3) : 568-574.
  • 5Ng :WK, Cheung LK, Li AS, et al. Thin-layer cytology findings of small cell carcinoma of the lower female genital tract. Review of three cases with molecular analysis[J]. Acta Cytol,2003,47(1) : 56- 64.
  • 6Tsunoda S,Jobo T,Arai M, et al. Small cell carcinoma of the u- terine cervix: a clinicopathologic study of 11 cases [J]. Int J Gy- necol Cancer, 2005,15 (2) : 295-300.
  • 7Lee SW, Nam J H,Kim DY, et al. Unfavorable prognosis of small cell neuroendocrine carcinoma of the uterine cervix[J]. Int J Gy- necol Cancer,2010,20(3) : 411- 416.
  • 8Lee JM, Lee KB, Nam JH, et al. Prognostic factors in FIGO stage IB-IIA small cell neuroen-docrine carcinoma of the uterine cervix treated surgically: results of amulti-center retrospective Korean study[J]. Ann Oncol,2008,19(2):321-326.
  • 9Zivanovic O, Leitao MM Jr, Park K J, et al. Small cell neuroendo- trine carcinoma of the cervix: analysis of outcome, recurrence pattern and the impact of platinum-based combination chemo- therapy [J]. Gynecol Oncol, 2009,112 (3) : 590-593.
  • 10Hoskins PJ, Swenerton KD, Pike JA, et al. Small-cell carcinoma of the cervix: fourteen years of experience at a single institution using a combined-modality regimen of involved-field irradiation and plat inure based combination chemotherapy [J]. Clin Oncol, 2003,21(18) : 3495-3501.

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山东医药
2012年 第33期

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