摘要
目的:观察根除幽门螺杆菌(Hp)对胰岛素抵抗(IR)、血脂及C反应蛋白(CRP)的影响。方法:92例确诊为Hp现症感染的患者随机分成治疗组和对照组,分别接受雷贝拉唑10 mg+克拉霉素500 mg+甲硝唑400mg,bid的根除Hp治疗和安慰剂。治疗前和8周后分别测定空腹血糖(FPG)、空腹胰岛素(FINS)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)及C反应蛋白(CRP)水平,计算稳态模型胰岛素抵抗指数(HOMA-IR)。结果:治疗组Hp根除率为78.2%(36/46)。治疗后治疗组Hp根除者TC、TG、LDL-C、CRP、HOMA-IR均显著下降,HDL-C显著上升(P<0.05)。对照组上述指标治疗前后无明显改变(P>0.05)。结论:Hp根除治疗能改善IR、血脂及CRP水平。
Objective：To investigate the effects of Hp eradication on insulin resistance（IR）,serum lipids and C reactive protein（CRP）.Methods：92 patients with Hp infection were randomly allocated to two groups of 46 patients each and treated with rabeprazole 10 mg＋clarithromycin 500 mg＋metronidazole 400 mg twice daily and placebo respectively for 7 days.HOMA-IR,TC,TG,LDL-C,HDL-C and CRP were measured before the eradication therapy and 8 weeks after its end in each group.Results：The eradication rate was 78.2%（36/46） in the treatment group.TC,TG,LDL-C,CRP,HOMA-IR in patients with successful eradication were significantly decreased and HDL-C was significantly increased from the pretreatment levels（P0.05）.Conclusion：Hp eradication can significantly improve their insulin resistance,serum lipids and C reactive protein.
出处
《药物流行病学杂志》
CAS
2012年第8期369-370,373,共3页
Chinese Journal of Pharmacoepidemiology
基金
佛山市卫生局基金资助项目(编号:2011366)
关键词
幽门螺杆菌
胰岛素抵抗
血脂
C反应蛋白
Helicobacter pylori
Eradication
Insulin resistance
Serum lipids
C reactive protein
