摘要
目的探讨烧伤和烧伤感染患者血小板微粒（platelet microparticles，PMPs）的变化及临床意义。方法选择烧伤休克期组（44例）、烧伤感染组（33例）和对照组（11例）患者，用流式细胞仪等方法检测血浆中PMPs水平，以绝对值和所占细胞微粒比例表示，同时检测临床常用生化指标．并分析与PMPs的相关性。结果烧伤休克期组和烧伤感染组CD41＋PMPs水平高于对照组（P〈0．01），且与烧伤面积呈正相关（r=0．258，P〈0．05）。多元逐步回归分析进入CD41＋PMPs水平回归方程的有γ-谷氨酰转肽酶（γ—GT）、烧伤面积和谷丙转氨酶（ALT）。结论烧伤患者PMPs水平升高可能与烧伤后凝血状态密切相关。
Objective To investigate the clinical significance of changes of platelet microparticles （PMPs） in burn and burn infection patients. Methods The patients were divided into burn shock group （ n = 44）, burn infection group （ n = 33 ） and control group （ n = 11 ）. Plasma PMPs were determined by flow cytometry and were recorded in absolute value and in particle proportion. Also, the frequently used biochemical indicators were detected and analyzed for their relationship with PMPs. Re- suits CD41 ＋ PMPs levels in the bum shock and bum infection groups were higher than those in the con- trol group （P 〈0.01 ） and they showed positive relation with extent of bum （r = 0. 258, P 〈 0.05）. Stepwise regression analysis indicated that r-glutamyltranspeptidase （r-GT）, extent of burn and alanine aminotransferase （ALT） entered CD41 ＋ PMPs level regression equation. Conclusion The increase of PMPs levels may be closely correlated with the pathological coagulation state in severe bum patients.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2012年第10期881-884,共4页
Chinese Journal of Trauma
基金
上海市科学委员会重点科研资助项目（08411952600）
关键词
烧伤
感染
血小板
Bums
Infection
Blood platelets
