摘要
目的:探讨125I粒子CT导向植入治疗恶性肿瘤多发腹膜后淋巴结转移的临床疗效及安全性。方法:根据放射性粒子植入计划系统(TPS系统),通过CT引导对33例患者共50组腹膜后淋巴结转移灶穿刺植入125I粒子,植入数量根据每个淋巴结转移灶的大小计算。术后1个月复查CT或MRI,测量转移灶大小变化情况,并通过判断疼痛程度评定患者生活质量变化情况。结果:50组腹膜后淋巴结转移灶均成功植入125I粒子;每组淋巴结转移灶植入10～100粒,平均46粒。术后1个月疗效评价:肿瘤完全缓解(CR)22组,部分缓解(PR)23组,无变化(NC)5组,无进展病例。125I粒子植入治疗有效率90.0%。疼痛缓解情况:术后1周疼痛明显缓解,24例中重度疼痛患者中20例明显或部分缓解,缓解率83.3%。术后随访3～20个月,3个月内无死亡病例,无严重不良反应。结论:CT引导下125I粒子植入治疗恶性肿瘤腹膜后淋巴结转移是短期疗效肯定而且安全的方法。
Objective：To evaluate the clinical efficacy and safety of CT-guided 125I seeds implantation for the treatment of multiple retroperitoneal lymph node metastases of malignant neoplasm.Methods：Based on the treatment planning system（TPS） of radiation seeds implantation,CT-guided 125I seed interstitial implantation was carried out in 33 patients with 50 groups of retroperitoneal lymph node metastases.The number of 125I seed implanted was calculated according to the size of individual metastatic lymph nodes.Follow-up CT or MRI was carried out one month after operation,the change of the size of metastatic lymph nodes was measured and the quantity of life was evaluated according to the change of the degree of pain.Results：125I seeds were implanted in 50 groups of metastatic retroperitoneal lymph node successfully,10 seeds to 100 seeds with the mean as 46 seeds were implanted in each group of lymph node.Complete remission（CR） was obtained in 22 groups,partial remission（PR） in 23 groups,no change（NC） in 5 groups and no progressive deterioration（PD） was showed 1 month after operation.The overall effective rate（CR＋PR） was 90.0%.The pain was relieved obviously in the following week and 24 patients with moderate to severe pain acquired apparent or partial relieved effect,the effective rate was 83.3%.Following-up for 3~20 months,no patient died and no serious complications was showed in 3 months.Conclusion：CT-guided 125I seed interstitial implantation for the treatment of retroperitoneal lymph node metastases was short-termed effective and safe.
出处
《放射学实践》
2012年第10期1128-1131,共4页
Radiologic Practice
